Abstract:

The characteristics and configuration of hepatocyte growthpromoting factor freeze-dried powder injection were studied with optical micrography and X-ray diffraction analysis，and the suitable freezedrying time of hepatocyte growthpromoting factor for injection was determined by the freezedrying testThe results indicated that the bulk drug and dextran had amorphous configurations and mannitol was crystalline and the freezedried powder included tiny mannitol crystals dispersed in the powder uniformlyThe crystal form of mannitol in the freezedried powder injection changed and the grains became tinierWhen the time for freezedrying was less than 30 h，the powder configuration was not homogeneousThe amorphous dextran was used as the protective agent and disperser for hepatocyte growthpromoting factor，the grains of mannitol constituted the framework of freezedried powder injectionIt was necessary to take 36 h to produce a good form of hepatocyte growthpromoting factor freezedried powder injection.