CIESC Journal
• 催化、动力学与反应器 • 上一篇 下一篇
戴立言 方俊 王晓钟 陈英奇
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摘要: 本文研究2-氨基吡啶及其衍生物的合成。目标产物以氰基吡啶为原料,以水和丙酮为混合溶剂,在稀碱溶液中,以过氧化氢为催化剂进行不完全水解,然后用新制的次溴酸钠进行霍夫曼降解反应制得。此合成路线周期简短,原料廉价易得,工艺操作简便,反应条件温和,具有较高的工业应用价值。
Abstract: The preparation of a series of 2-pyridinamines and their alkyl derivatives is described.The target compounds are synthesized starting from corresponding 2-cyanopyridines, via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alkaline mixture of acetone-2% sodium hydroxide solution, and Hoffmann degradation reaction with freshly made NaBrO.This route is of industrial value because of cheap and readily available materials, moderate reaction conditions and convenient operations.
戴立言 方俊 王晓钟 陈英奇. 由2-氰基吡啶合成2-氨基吡啶及其烷基衍生物 [J]. CIESC Journal.
. Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines[J]. .
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https://hgxb.cip.com.cn/CN/Y2007/V58/I3/670