Abstract: The simple metalloporphyrins TPPMCl (M=Fe,Mn) and TPPM (M=Co,Cu) are generally used to catalyze the aerobic oxidation of cyclohexane to KA oil (cyclohexanol and cyclohexanone) and adipic acid.By using orthogonal design,the influence of reaction temperature, the air flow rate, the reaction time,amount of catalyst and pressure on the cyclohexane aerobic oxidation over TPPMnCl was studied, and the optimized conditions for the cyclohexane oxidation with air catalyzed by TPPMnCl were obtained.Range analysis results of the above five factors were 6.17, 3.12, 2.25, 1.81, 1.53 respectively by taking the total yield(including cyclohexanol,cyclohexanone and adipic acid) as the evaluation index,indicating that reaction temperature was the key factor.Under the optimized conditions of reaction temperature 150℃, pressure 1.2 MPa, air flow rate 0.13 m3·h-1, 7 mg of TPPMnCl , and reaction time 3.5 h, the conversion of cyclohexane was 20.0%, the total selectivity was 90.0%, and the selectivity of adipic acid could go up to 21.0%.