高温液态水中腺苷无催化水解反应动力学

化工学报 ›› 2008, Vol. 59 ›› Issue (10): 2531-2535.

• 催化、动力学与反应器 • 上一篇下一篇

高温液态水中腺苷无催化水解反应动力学

傅杰;吕秀阳

浙江大学化学工程与生物工程学系

出版日期:2008-10-05 发布日期:2008-10-05

Kinetics of non-catalyzed hydrolysis of adenosine in high temperature liquid water

FU Jie; Lv Xiuyang

Online:2008-10-05 Published:2008-10-05

摘要/Abstract

摘要： 腺嘌呤作为一种重要的化工原料，已广泛应用于医药、有机合成等领域，目前腺嘌呤采用丙二酸二乙酯与甲酰胺缩合反应合成，环境污染较大。为实现腺嘌呤生产的绿色化，同时探索腺苷中C-N断裂的机理，开展了在高温液态水中无催化腺苷水解反应的研究，考察了高温液态水中初始浓度、搅拌速率、温度对腺苷水解的影响，研究了150～190 ℃下腺苷的水解反应动力学，在假设反应为零级反应的情况下拟合得到了各温度的反应速率常数，并得出活化能为174.1 kJ•mol-1。实验结果表明，高温水解中腺苷无催化水解制备腺嘌呤是可行的，而且产率较高。

关键词:

腺苷, 无催化水解, 腺嘌呤, 高温液态水

Abstract:

Adenine is an important chemical material widely used in the fields of medicine, organic synthesis and so onPresently, adenine is produced from the condensation of diethyl malonate with formamide, which has serious pollution problemsTo achieve the green production of adenine, noncatalyzed hydrolysis of adenosine in high temperature liquid water was carried outThe effects of initial concentration, agitating speed and temperature on adenosine hydrolysis were studied and the kinetics of adenosine hydrolysis was investigated at temperatures from 150℃ to 190℃Rate constants were evaluated with the zeroth-order reaction assumption and the activation energy was 134.1 kJ·mol^-1The experimental results demonstrated that high selective preparation of adenine by non-catalyzed hydrolysis of adenosine in high temperature liquid water was possible.

Key words:

腺苷, 无催化水解, 腺嘌呤, 高温液态水

傅杰, 吕秀阳. 高温液态水中腺苷无催化水解反应动力学 [J]. 化工学报, 2008, 59(10): 2531-2535.

FU Jie, Lv Xiuyang. Kinetics of non-catalyzed hydrolysis of adenosine in high temperature liquid water[J]. CIESC Journal, 2008, 59(10): 2531-2535.

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高温液态水中腺苷无催化水解反应动力学

Kinetics of non-catalyzed hydrolysis of adenosine in high temperature liquid water

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