Abstract:

Diffusion of magnetic fluid and energy transport in the tumor are crucial processes for magnetic fluid hyperthermia and play an important role in tumor treatment.A coupled numerical simulation，including a fluid transport model，a solute transport model and a heat transfer model，was developed to investigate the diffusion process of magnetic fluid and the temperature rise in the tumor tissue in alternating magnetic field.The finite element method was applied to the calculations，and the pressure distribution，concentration distribution，and temperature distribution were obtained.Moreover，the effects of the diffusion time of the magnetic fluid，the number of injection points and the specific absorption rate（SAR）on temperature distributions were analyzed.The results showed that the increases of the diffusion time and the number of injection points caused the volume of tumor tissues with the desired necrosis temperature to increase，and decrease the highest heating temperature of the tumor tissue as well.An increase in the SAR always resulted in an obvious increase in the volume of tumor tissues with the desired necrosis temperature.However，the temperature of the normal tissue also increased with the increase of SAR，which might cause dangers in clinical treatments when it was higher than the safety temperature.