有序介孔材料作为药物控释载体的研究进展

CIESC Journal

有序介孔材料作为药物控释载体的研究进展

许云强，周国伟，李艳敬，白光伟

山东轻工业学院化学工程学院，山东省轻工助剂重点实验室

出版日期:2010-07-28 发布日期:2010-12-30

Progress in ordered mesoporous materials as controlled drug release carriers

XU Yunqiang，ZHOU Guowei，LI Yanjing，BAI Guangwei

School of Chemical Engineering，Shandong Institute of Light Industry，Key Lab for Fine Chemicals of
Shandong Province

Online:2010-07-28 Published:2010-12-30

摘要/Abstract

摘要： 有序介孔材料具有较高的比表面积、孔体积和可调控的孔道结构，被广泛应用为药物控释的载体。综述了不同种类有序介孔材料载体的药物控释行为及其影响因素：有序介孔材料经表面改性处理后，能改善其对药物控释的能力，包括提高药物负载量以及减缓药物释放速率。通过控释，药物的药效持久性和治疗效果得以提高，并能实现靶向给药。对其应用前景进行了展望。

Abstract: Ordered mesoporous materials have been widely employed as carriers for controlled drug release due to their high specific surface areas，pore volumes and regulated pore channels. The controlled drug release capacities of ordered mesoporous materials can be improved upon surface modification，such as drug loading amount and enhancement and drug release rate reduction. The controlled drug release can improve the drug persistent efficacy and therapeutic efficiency，and achieve targeted drug delivery. Different ordered mesoporous materials as carriers for controlled drug release and influence factors are reviewed，and their application prospects are predicted.

许云强，周国伟，李艳敬，白光伟. 有序介孔材料作为药物控释载体的研究进展 [J]. CIESC Journal.

XU Yunqiang，ZHOU Guowei，LI Yanjing，BAI Guangwei. Progress in ordered mesoporous materials as controlled drug release carriers[J]. .