Abstract: This review summarizes the chemical and biological synthesis for xylonic acid production. By comparison，the microbial fermentation method is considered as one of the promising methods for xylonic acid production. Current status of microbial xylonic acid production is especially introduced，including strains，metabolite pathways and fermentation levels. In addition，the application prospects of xylonic acid is also discussed. It is proposed that future research should be emphasized on screening ideal microbe strains，analysis in the metabolic mechanism for xylose oxidation，and further investigation in xylonic acid application.