CIESC Journal

• 生物化工 • 上一篇    下一篇

高载药量海藻酸钙/几丁聚糖微胶囊的性能

孙学战1,刘源岗1,2,王士斌1,2,蓝 琪1   

  1. 1 华侨大学化工学院,福建 厦门 361021;2华侨大学制药工程研究所,福建 厦门 361021
  • 出版日期:2010-09-25 发布日期:2010-11-15

Properties of calcium alginate/chitosan microcapsules with high

SUN Xuezhan1,LIU Yuangang1,2,WANG Shibin1,2,LAN Qi1   

  1. 1 College of Chemical Engineering,Huaqiao University,Xiamen 361021,Fujian,China;
  • Online:2010-09-25 Published:2010-11-15

摘要:

采用乳化固化法制备了平均粒径为820 nm海藻酸钙微球,并制备了海藻酸钙/几丁聚糖微胶囊。以牛血清白蛋白(BSA)为模型药物,考察投药浓度、几丁聚糖分子量和浓度等对微胶囊载药量和药物释放的影响,发现其载药量最大可达40%以上,结果还显示这种微胶囊具有很好的体外缓释性能。

Abstract:

Calcium alginate microspheres with mean diameter of 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing. Effects of drug concentrationthe molecular weight and concentration of chitosan on drug-loading and drug-release of the microcapsules were investigated using bovine serum albuminBSAas a model drug. The maximum drug-loading was over 40%and the microcapsules also showed good property of sustained-release in vitro.