CIESC Journal
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郭建峰, 高保娇, 张正国
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GUO Jianfeng, GAO Baojiao, ZHANG Zhengguo
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Abstract:
Poly 4-vinyl pyridine/SiO2 (P4VP/SiO2), a grafted functional particles, was prepared by grafting 4-vinyl pyridine (4VP)on micro-sized silica gel particles with the “graft from” method, using 3-methacryloxypropyl trimethoxysilane (MPS)as coupling agent. Subsequently, by using the novel surface-molecular imprinting technique, the L-Glu molecule-imprinted material MIP-P4VP/SiO2 was prepared by imprinting towards the grafted P4VP with L-Glu, one enantiomer of glutamic acid (Glu), as template molecule and 1,6-dibromohexane as crosslinking agent. The recognition characteristics of MIP-P4VP/SiO2 for L-Glu was studied by both static method and dynamic method in which D-Glu was used as a contrast compound. The separation ability of MIP-P4VP/SiO2 towards L-Glu and D-Glu in the racemic solution was examined. The experiment results showed that MIP-P4VP/SiO2 had obvious recognition selectivity and fine binding affinity for L-Glu, and the selectivity coefficient was equal to 3.38 with respect to D-Glu, displaying the fine separation property for the enantiomers of glutamic acid. Besides, MIP-P4VP/SiO2 had excellent elution property with diluted aqueous solution of NaOH as eluent, the desorption ratios of L-Glu could reach 99.53% in 12 BV. Moreover, this material showed effective separation ability of repeated use for more than ten times.
中图分类号:
10. 3969/j. issn. 0438-1157. 2011. 11. 033
郭建峰, 高保娇, 张正国. 新型表面印迹材料MIP-P4VP/SiO2对谷氨酸对映体的手性拆分[J]. CIESC Journal.
GUO Jianfeng, GAO Baojiao, ZHANG Zhengguo. Realizating chiral separation of enantiomers of glutamic acid with novel surface-molecular imprinting technique[J]. .
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