关键词: 光响应, 偶氮苯, 螺吡喃, 香豆素, 邻硝基苯衍生物

Abstract: Photo-responsive drug delivery systems（Pr-DDS）stands out as a clean and noninvasive DDS. For Pr-DDS，the release of entrapped drugs can be accelerated at a specific location and time upon light-activation，which promotes maximum efficacy. The typical chromophores，incorporated into the photo-responsive drug release systems to render it susceptible to light trigger，include azobenzene（photoisomerization type），spiropyran（formation of zwitterionic species），coumarin（formation of the photo-cross-linking structure），and nitrobenzyl esters（conversion from hydrophobic to hydrophilic block）. In this paper，the progress in Pr-DDS development has been reviewed according to their different chromophores，and their application is also involved. Among these four Pr-DDS，Azo，as the representatives of the photoisomerization type，is the most widely studied one，which involves themicelles，vesicles，hydrogels，liposomes，etc. And nitrobenzyl ester，as the representatives of the conversion from hydrophobic to hydrophilic block type，has attracted wide attention for the two-photon response capability. In conclusion，although great progresses had been made on Pr-DDS，but there were still many problems，including how to improve the biocompatibility，and how to achieve feasible targeted light-controlled release in vivo.

Key words: photo-responsive, azobenzene, spiropyran, coumarin, o-nitrophenyl derivative