关键词: 反应分离耦合, 传质方程, 最佳耦合点, 甘露醇

Abstract: A coupling modeling method for integrated control was proposed for determining the optimal coupling point of chemical reaction and separation. Based on the principles of electrochemical reduction reaction and continuous chromatographic separation，the mass transfer equations of reaction and separation were simultaneously solved by using the concentration of electrochemical reaction as the initial boundary conditions for the inputs of the mass transfer equations of continuous chromatographic separation. The influence among the conversion rate of products，the separating efficiency and the electrochemical reaction time were disclosed. The demonstration for the potential of this modeling method was given by its application for the preparation of mannitol. The results showed satisfactory agreement with the experimental data. The method can be effectively used to predict the optimal coupling point of reaction and separation for mannitol preparation，and has the certain promotion application value.

Key words: reaction-separation coupling, mass transfer equation, optimal coupling point, mannitol