高山被孢霉菌丝形态结构及其对产花生四烯酸油脂影响的研究进展

化工进展

高山被孢霉菌丝形态结构及其对产花生四烯酸油脂影响的研究进展

张瑷珲，纪晓俊，聂志奎，任路静，黄和

南京工业大学生物与制药工程学院，材料化学工程国家重点实验室，江苏南京 210009

出版日期:2013-05-05 发布日期:2013-05-25

Progress in influence factors on morphology of Mortierella alpina producing arachidonic acid-rich oil

张瑷珲，纪晓俊，聂志奎，任路静，黄和

State Key Laboratory of Materials-Oriented Chemical Engineering，College of Biotechnology and Pharmaceutical Engineering，Nanjing University of Technology，Nanjing 210009，Jiangsu，China

Online:2013-05-05 Published:2013-05-25

摘要/Abstract

摘要： 花生四烯酸是人体必需的多不饱和脂肪酸之一，因其在食品和医药等领域有着广泛应用而得到人们越来越多的关注。当前利用高山被孢霉发酵法生产富含花生四烯酸的油脂已成为花生四烯酸的主要来源。发酵过程中，合适的菌体形态对花生四烯酸油脂的高效生产极为重要。本文总结了在高山被孢霉培养过程中，氮源、消耗的碳氮比、氨基酸、无机盐、溶氧等因素对其形态的影响，各种形态特征对花生四烯酸油脂产量的影响以及培养过程中的形态控制策略。提出以后研究工作的重点是进一步探究影响高山被孢霉形态的因素，建立与花生四烯酸油脂产量相关联的形态学参数标准，以此来指导工业生产过程中良好形态的精确控制。

关键词: 花生四烯酸油脂, 高山被孢霉, 形态学参数

Abstract: Arachidonic acid，which is an essential polyunsaturated fatty acid in human nutrition，generally exists in the form of triglyceride. It has got more and more attention in food，medicine and other fields. At present，the main sources of arachidonic acid is from fermentation by the fungus of Mortierella alpina. The control of mycelia morphology plays a vital role in the whole fermentation process. In this review，the influence factors including nitrogen source，consumed carbon to nitrogen ratio，amino acid，mineral addition and dissolved oxygen on the fungus morphology were summarized. Some efficient morphology control strategies for arachidonic acid production by the fungus were presented. Future research should be focused on exploring the effect on morphology of M. alpina by many other factors，and establishing the relationship between morphology parameters and yield of arachidonic acid，which would guide the accurate control of morphology in industrial fermentation process.

Key words: arachidonic acid-rich oil, Mortierella alpina, morphology parameters

张瑷珲，纪晓俊，聂志奎，任路静，黄和. 高山被孢霉菌丝形态结构及其对产花生四烯酸油脂影响的研究进展[J]. 化工进展.

张瑷珲，纪晓俊，聂志奎，任路静，黄和. Progress in influence factors on morphology of Mortierella alpina producing arachidonic acid-rich oil[J]. Chemical Industry and Engineering Progree.