关键词: 对甲基苯基氯化镁, 格氏试剂, 2-甲基四氢呋喃-四氢呋喃, 混合溶剂

Abstract: p-Tolylmagnesium halide is an important raw material for synthesizing 2-cyano-4’-methyl- biphenyl (OTBN)，which is a key intermediate of the latest generation of anti-hypertensive drugs. Due to hard initiation，the cheaper chlorotoluene has not been used for synthesizing the above Grignard reagent of p-tolylmagnesium chloride. With magnesium and chlorotoluene as starting materials，p-tolylmagnesium chloride was synthesized via Grignard reaction using 2-methyltetrahydrofuran and tetrahydrofuran as mixed solvent. The synthesis process of the Grignard reagent was optimized with a 95.4% yield of target product. Comparing with the cases of traditional preparation process，the technique offered a new one with lower reactor anhydration，simplified operation and raised product yield. This new technique provides a feasible route for thesynthesis of p-tolylmagnesium halide，which can significantly reduce the cost of raw material for synthesizing OTBN.

Key words: p-tolylmagnesium chloride, Grignard reagent, 2-methyltetrahydrofuran-tetrahydrofuran, mixed solvent