2,3-丁二醇的发酵生产

CIESC Journal

2,3-丁二醇的发酵生产

宋源泉，许赟珍，李强，刘德华

清华大学化学工程系，北京 100084

出版日期:2011-05-05 发布日期:2011-06-13

Fermentation of bio-based product 2,3-butanediol

SONG Yuanquan，XU Yunzhen，LI Qiang，LIU Dehua

Department of Chemical Engineering，Tsinghua University，Beijing 100084，China

Online:2011-05-05 Published:2011-06-13

摘要/Abstract

摘要：

能源危机和环境污染使得化工行业的发展举步维艰，亟待开发新的发展模式，以可再生能源为原料的生物炼制技术成为可行的途径之一。2,3-丁二醇的发酵生产是现代生物炼制的重要课题之一。2,3-丁二醇作为一种大宗的化学产品具有广泛的应用价值，尤其在化工、食品、燃料、医药等领域。本文简要描述了2,3-丁二醇在微生物体内的代谢途径，着重讨论了2,3-丁二醇的发酵生产，对发酵的菌种种类、菌种诱变和定向改造、各种发酵影响因素（包括底物、pH值、溶氧、温度以及发酵方式）进行了详细的归纳总结，同时展望了2,3-丁二醇发酵生产的研究发展方向。

Abstract:

The development of chemical industry is hindered by energy crisis and environment pollution，and a new model of development is urgently to be exploited. Biorefining technology with renewable resources as feedstock is proposed as one possible solution，in which 2,3-butanediol fermentation is one important issue. 2,3-Butanediol，a bulk chemical product，has extensive applications，especially in chemical processes，food，fuel and medicine. The metabolic pathway of 2,3-butanediol is briefly described，and the progress of biotechnological production of 2,3-butanediol is reviewed，including microbial strains，strains mutagenization，genetic modifications and operating conditions (substrates，pH value，aeration，temperature and fermentation mode). Finally，2,3-butanediol fermentation research directions are proposed.

宋源泉，许赟珍，李强，刘德华. 2,3-丁二醇的发酵生产 [J]. CIESC Journal.

SONG Yuanquan，XU Yunzhen，LI Qiang，LIU Dehua . Fermentation of bio-based product 2,3-butanediol[J]. .