CIESC Journal
• 生物化工 • 上一篇 下一篇
孙学战1,刘源岗1,2,王士斌1,2,蓝 琪1
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SUN Xuezhan1,LIU Yuangang1,2,WANG Shibin1,2,LAN Qi1
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摘要:
采用乳化固化法制备了平均粒径为820 nm海藻酸钙微球,并制备了海藻酸钙/几丁聚糖微胶囊。以牛血清白蛋白(BSA)为模型药物,考察投药浓度、几丁聚糖分子量和浓度等对微胶囊载药量和药物释放的影响,发现其载药量最大可达40%以上,结果还显示这种微胶囊具有很好的体外缓释性能。
Abstract:
Calcium alginate microspheres with mean diameter of 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing. Effects of drug concentration,the molecular weight and concentration of chitosan on drug-loading and drug-release of the microcapsules were investigated using bovine serum albumin(BSA)as a model drug. The maximum drug-loading was over 40%,and the microcapsules also showed good property of sustained-release in vitro.
孙学战1,刘源岗1,2,王士斌1,2,蓝 琪1. 高载药量海藻酸钙/几丁聚糖微胶囊的性能 [J]. CIESC Journal.
SUN Xuezhan1,LIU Yuangang1,2,WANG Shibin1,2,LAN Qi1. Properties of calcium alginate/chitosan microcapsules with high[J]. .
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https://hgxb.cip.com.cn/CN/Y2010/V29/I9/1725