Abstract:

Effects of molecular weight（M_w）of chitosan，ratio of chitosan and collagen，content of cross-linker were investigated in order to improve the properties of compound chitosan-collage sponge. Optimum preparation conditions were obtained：M_w of chitosan 1.5×10⁵，ratio of chitosan and collagen 2∶3，amount of glutaricdialdehyde 1.5%. The aperture of compound sponge obtained under optimum conditions was between 100 μm and 150 μm measured by SEM and the physical properties of sponge met the requirements.

摘要：

为了改善壳聚糖/胶原蛋白复合海绵辅料的性能，研究了壳聚糖相对分子质量、壳聚糖/胶原蛋白配比、交联剂用量的影响，并得出最佳条件。优化后的制备条件为壳聚糖相对分子质量为1.5×10⁵ Da、壳聚糖与胶原蛋白质量比为2∶3、戊二醛添加量为1.5%，得到的复合海绵的各项性能都较好。扫描电镜观察复合海绵的孔径大小为100～150 μm，排列有序，各项物理性能指标基本符合要求。