Abstract:

The preparation of β-cyclodextrin microspheres was optimized by using U13*（13⁴）uniform design. The result showed that the optimμm reaction temperature was 80 ℃，reaction time was 4 h，the amount of crosslinker was 8 g and stirring speed was 1000 r/min. The factors affecting microsphere size were stirring speed，and reaction temperature. The factors affecting yield were crosslinking agent，and reaction time. The surface of those β-CD microspheres under optimal conditions was smooth and had good thermal stability.

摘要：

为了优化β-环糊精微球的制备工艺，采用U₁₃*（13⁴）均匀设计对合成工艺优化，得出最佳合成工艺为反应温度80 ℃，反应时间4 h，交联剂的用量8 g，搅拌速度1000 r/min。影响微球粒径的因素：搅拌速度>反应温度。影响产量的因素：交联剂的用量>反应时间。最佳合成工艺下的微球表面圆整，具有较好的热稳定性。