Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode

doi:10.3969/j.issn.0438-1157.2014.01.038

CIESC Journal ›› 2014, Vol. 65 ›› Issue (1): 292-297.DOI: 10.3969/j.issn.0438-1157.2014.01.038

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Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode

NIU Dongfang¹, WANG Haiyang¹, YU Qiuyan², ZHANG Xinsheng¹

1 State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China;
2 Zhejiang Jiuzhou Pharmaceutical. Co., Ltd., Hangzhou 310051, Zhejiang, China

Received:2013-06-20 Revised:2013-08-31 Online:2014-01-05 Published:2014-01-05

5-硝基苯并咪唑酮在铜网电极上还原制备5-氨基苯并咪唑酮

钮东方¹, 王海洋¹, 俞秋雁², 张新胜¹

1 化学工程联合国家重点实验室(华东理工大学), 上海 200237;
2 浙江九洲药物科技有限公司, 浙江杭州 310051

通讯作者: 张新胜
作者简介:第一作者：钮东方（1982-），男，讲师。

Abstract

Abstract: 5-aminobenzimidazolone was prepared by electro-reduction of 5-nitrobenzimidazolone on copper mesh cathode. The electrochemical behavior was studied on Cu micro-electrode by cyclic voltammetry, and the result indicated that the electrochemical reduction of 5-nitrobenzimidazolone was an irreversible reaction controlled by diffusion. Influence of some key factors (such as nature of cathode material, current density, temperature and passed charge) on this reaction was investigated. Under the optimized condition, the yield of 5-aminobenzimidazolone reached 93%. The yield of 5-aminobenzimidazolone could still be maintained at about 93% after the catholyte was continuously recycled 10 times, corresponding to the effect of fresh catholyte.

Key words: copper mesh electrode, electro-reduction, 5-nitrobenzimidazolone, 5-aminobenzimidazolone, recycle of catholyte

摘要： 研究了以5-硝基苯并咪唑酮为原料在铜网电极上还原制备5-氨基苯并咪唑酮的反应。循环伏安结果表明5-硝基苯并咪唑酮的电化学还原是一受扩散控制的不可逆反应；探讨了电极材料、电流密度、温度和通电量对产物产率的影响，在最优条件下5-氨基苯并咪唑酮的产率可达93%；电解液连续套用10次后，5-氨基苯并咪唑酮产率仍然可以维持在93%左右，与新鲜电解液效果相当。

关键词: 铜网电极, 电化学还原, 5-硝基苯并咪唑酮, 5-氨基苯并咪唑酮, 电解液循环

CLC Number:

TQ316.33

NIU Dongfang, WANG Haiyang, YU Qiuyan, ZHANG Xinsheng. Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode[J]. CIESC Journal, 2014, 65(1): 292-297.

钮东方, 王海洋, 俞秋雁, 张新胜. 5-硝基苯并咪唑酮在铜网电极上还原制备5-氨基苯并咪唑酮[J]. 化工学报, 2014, 65(1): 292-297.

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Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode

5-硝基苯并咪唑酮在铜网电极上还原制备5-氨基苯并咪唑酮

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