CIESC Journal ›› 2008, Vol. 59 ›› Issue (8): 2041-2045.
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MA Shaoling; LU Zhaowen;BI Erli;WU Youting;ZHANG Zhibing;MENG Weimin
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马少玲;陆兆文;毕二利;吴有庭;张志炳;孟为民
Abstract:
A high-pressure quartz crystal microbalance (QCM) apparatus was developed to investigate the absorption of carbon dioxide in two glassy polymer films—polystyrene (PS) and polyvinylpyrrolidone (PVP) at 40℃ and pressure up to 9.0 MPa.PVP was shown to have better CO2 absorption and chosen as the representative for supercritical impregnation of two model drugs—o-aminobenzoic acid and ibuprofen at 40℃ and pressure up to 8.0 MPa.It was found that the two impregnants were embedded into the polymer with a partition coefficient as high as 104 order of magnitude.Since the sub-microweighing technique established and utilized in this study was simple, convenient and accurate, it was believed that the technique could have wide and effective applications in supercritical impregnation processes.
Key words: 石英晶体微天平(介微称重技术), 超临界流体掺杂, 药物, 聚合物, 分配
石英晶体微天平(介微称重技术),
关键词: 石英晶体微天平(介微称重技术), 超临界流体掺杂, 药物, 聚合物, 分配
MA Shaoling, LU Zhaowen, BI Erli, WU Youting, ZHANG Zhibing, MENG Weimin. Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer[J]. CIESC Journal, 2008, 59(8): 2041-2045.
马少玲, 陆兆文, 毕二利, 吴有庭, 张志炳, 孟为民. 介微称重技术测定药物在超临界流体和被掺杂聚合物间的分配 [J]. 化工学报, 2008, 59(8): 2041-2045.
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