Abstract: The enantiomers of omeprazole were resolved by simulated moving bed chromatography on the coated cellulose triphenylcarbamate chiral stationary phase using ethanol as mobile phase.The effects of columns switching time and recycling flow rate on separation were investigated.Under the experimental conditions, as the switching time was increased, the concentration, productivity and recovery of S-omeprazole were increased, while the consumption of eluent and the purity of enantiomer were decreased.Decreasing recycling flow rate could improve separation, and the highest purity of the two enantiomers was 96.4%(S) and 88.4%(R) respectively.

Key words: 奥美拉唑, 模拟移动床, 对映体, 拆分

摘要： 以乙醇为流动相，用纤维素三苯基氨基甲酸酯涂敷型手性固定相在模拟移动床色谱上拆分了奥美拉唑对映体.研究了柱子切换时间以及流动相内部流速对分离效果的影响.实验条件下，S-奥美拉唑的浓度、产率和回收率随切换时间增加而增加，流动相消耗和纯度则随之降低.降低内部流速，有利于改善分离，S-奥美拉唑的纯度最高可达96.4%，R-奥美拉唑的纯度最高为88.4%.

关键词: 奥美拉唑, 模拟移动床, 对映体, 拆分