Synthesis of 3-oxo-4-aza-5-androstene-17-oxime derivatives
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YANG Xiongwen;ZHU Kongming;LIU Dongzhi;ZHOU Xueqin
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3-羰基-4-氮杂-5-雄甾烯-17-肟衍生物的合成
杨雄文;朱孔明;刘东志;周雪琴
天津大学化工学院,天津 300072
Abstract: 4-Azasteroids as important 5α-reductase inhibitors play a critical role in therapy of several human endocrine diseases, such as benign prostatic hyperplasia, male pattern baldness, female hirsutism, etc. Starting from 4-androstenedione, three novel 3-oxo-4-aza-5-androstene-17-oxime derivatives 7, 8 and 9 were synthesized through oxidation ring cleavage, amination ring closure, oximation,and substitution. The structures of these novel compounds were identified with MS,1H NMR and 13C NMR.
摘要: 4-氮杂类甾体化合物是一类比较重要的治疗良性前列腺增生、男性秃顶、女性多毛等症状的5α-还原酶抑制剂.以4-雄烯二酮为起始原料,经过氧化开环、氨解闭环、肟化、取代等4步反应,合成了3个新的3-羰基-4-氮杂-5-雄甾烯-17-肟衍生物7、8和9,并用质谱、1H NMR、13C NMR等测试手段对目标化合物的结构进行了表征.
YANG Xiongwen;ZHU Kongming;LIU Dongzhi;ZHOU Xueqin.
杨雄文;朱孔明;刘东志;周雪琴 .
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https://hgxb.cip.com.cn/EN/Y2006/V57/I4/898