Abstract: The adsorption mechanism of coated activated carbon was analysed and the mathematical model of hemoperfusion process was established. The results of treating 20 groups of data of pig blood perfusion in vitro showed that the calculation values could fit the experimental data well, the adsorption equilibrium could be described as Langmuir equation, the adsorption rate controlling step of creatinine was the outside diffusion, but that of inulin was the inside diffusion or the coordination of both the outside and the inside diffusion. The influence of the ratio of height to diameter on hemoperfusion process was little.

摘要： 从包囊活性炭吸附机理出发,建立了血液灌流过程数学模型,并对20组猪全血离体灌流实验数据进行了处理。结果表明,本文所建模型能较好地描述血液灌流过程,计算值与实验数据吻合良好。用所得模型参数分析了血液灌流过程特性,结果表明,肌酐和菊糖在血液中的吸附平衡遵循Langmuir方程;肌酐的吸附速率受外扩散控制,菊糖则受内扩散控制,或两者同时控制;高径比对血液灌流的影响较小。