Abstract: The intrinsic kinetic model for oxidative dehydrogenation of butene to butadiene over B02 catalyst was studied in an internal recirculation gradientless reactor by the sequential experiment design method, Hook -Jeeve and maximum likelihood method. Among 28 possible models based on a consecutive - parallel reaction network a model with the best fit was obtained as follows Where Dependence of selectivity with respect to butadiene on the partial pressures of oxygen, butene, butadiene and reaction temperature is as follows significance test indicated that reaction temperature was the main factor.