CIESC Journal ›› 2010, Vol. 18 ›› Issue (3): 425-445.

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Effect of Temperature on Volumetric and Viscometric Properties of Homologous Amino Acids in Aqueous Solutions of Metformin Hydrochloride

K. Rajagopal1, S. S. Jayabalakrishnan2   

  1. 1. Department of Physics, Government College of Engineering Tirunelveli-627007 Tamil Nadu, India;
    2. Department of Physics, P. S. R. Engineering College, Sivakasi-626 140 Tamil Nadu, India
  • 收稿日期:2009-06-19 修回日期:2009-12-09 出版日期:2010-06-28 发布日期:2010-06-28
  • 通讯作者: S. S. Jayabalakrishnan,E-mail:krishnanpsr@yahoo.com

Effect of Temperature on Volumetric and Viscometric Properties of Homologous Amino Acids in Aqueous Solutions of Metformin Hydrochloride

K. Rajagopal1, S. S. Jayabalakrishnan2   

  1. 1. Department of Physics, Government College of Engineering Tirunelveli-627007 Tamil Nadu, India;
    2. Department of Physics, P. S. R. Engineering College, Sivakasi-626 140 Tamil Nadu, India
  • Received:2009-06-19 Revised:2009-12-09 Online:2010-06-28 Published:2010-06-28

摘要: Density(ρ)and viscosity(η)are measured for glycine,DL-α-alanine DL-α-valine,and DL-α-leucine in 0.05,0.10,0.15 and 0.20 mol·L-1 aqueous metformin hydrochloride at 308.15,313.15 and 318.15 K.The measured values are used to estimate some important parameters,such as partial molal volume Vφ,standard partial molal volume Vφ0,transfer volume ΔVφ0,hydration number nH,the second derivative of infinite dilution of partial molal volume with respect to temperature,viz.,∂2Vφ0/∂T2,viscosity B-coefficient,variation of B with temperature,viz., dB/dT,free energy of activation per mole of solvent Δμ10 and solute Δμ20 of the amino acids.These parameters are interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.In addition,Vφ0, ΔVφ0,viscosity B-coefficient,ΔB and Δμ20 are split into group contributions(NH3+COO-)and —CH2 of the amino acids using their linear correlation and their behavior is discussed.

关键词: standard partial molal volume, transfer volume, hydration number, viscosity B-coefficient, activation energy, metformin hydrochloride

Abstract: Density(ρ)and viscosity(η)are measured for glycine,DL-α-alanine DL-α-valine,and DL-α-leucine in 0.05,0.10,0.15 and 0.20 mol·L-1 aqueous metformin hydrochloride at 308.15,313.15 and 318.15 K.The measured values are used to estimate some important parameters,such as partial molal volume Vφ,standard partial molal volume Vφ0,transfer volume ΔVφ0,hydration number nH,the second derivative of infinite dilution of partial molal volume with respect to temperature,viz.,∂2Vφ0/∂T2,viscosity B-coefficient,variation of B with temperature,viz., dB/dT,free energy of activation per mole of solvent Δμ10 and solute Δμ20 of the amino acids.These parameters are interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.In addition,Vφ0, ΔVφ0,viscosity B-coefficient,ΔB and Δμ20 are split into group contributions(NH3+COO-)and —CH2 of the amino acids using their linear correlation and their behavior is discussed.

Key words: standard partial molal volume, transfer volume, hydration number, viscosity B-coefficient, activation energy, metformin hydrochloride