聚合物阵列微针及其在透皮给药系统的应用

doi:10.11949/0438-1157.20191175

摘要/Abstract

摘要：

阵列微针作为一种新型透皮给药方式，能够避免皮肤角质层的屏障作用，实现亲水性药物和生物大分子药物的高效透皮吸收，具有无痛、微创、高效等优点。聚合物阵列微针的制备材料和制备方法多种多样，其不仅具有其他阵列微针的优点，还具有生物相容性好、安全性高、载药量精确可控及制备成本低廉等优势，是目前研究最为广泛且最具应用前景的一类阵列微针。系统地综述了目前聚合物阵列微针的主要制备方法及其在透皮给药系统中的最新研究进展。

关键词: 聚合物阵列微针, 透皮给药, 肿瘤治疗, 糖尿病治疗, 疫苗接种

Abstract:

Microneedle arrays, which can avoid the barrier effect of the stratum corneum and enhance the permeability across skin for hydrophilic drugs and biological macromolecules, are a novel model for transdermal drug delivery. Microneedle arrays have been widely studied because they are featured with painless, minimally invasive and efficient properties. There are many polymeric materials and manufacturing methods for polymeric microneedle arrays; therefore, the polymeric microneedle arrays not only have the advantages of other microneedle arrays, but also have the advantages of good biocompatibility, safety, accurate and controllable drug loading and low cost, etc. The polymeric microneedle arrays are the most widely studied and most promising microneedle arrays. This paper systematically reviews the main preparation methods of polymer array microneedles and the latest research progress in transdermal drug delivery systems.

Key words: polymeric microneedle arrays, transdermal drug delivery, tumor therapy, diabetes therapy, vaccination

中图分类号:

TQ 021

蒲兴群, 巨晓洁, 谢锐, 汪伟, 刘壮, 褚良银. 聚合物阵列微针及其在透皮给药系统的应用[J]. 化工学报, 2020, 71(1): 43-53.

Xingqun PU, Xiaojie JU, Rui XIE, Wei WANG, Zhuang LIU, Liangyin CHU. Polymeric microneedle arrays for applications in transdermal drug delivery systems[J]. CIESC Journal, 2020, 71(1): 43-53.

图/表 6

图1 微模板法制备聚合物阵列微针的示意图(a)浇铸法[31]; (b)注塑成型法和热压印法[36]

Fig.1 Schematic illustration of micro-molding methods(a) casting [31]; (b) injection moulding and hot embossing [36]

图2 拉伸法制备聚合物阵列微针的示意图(a)立体平板拉伸法[56]；(b)液滴吹气法[60]；(c)离心拉伸法[61]；(d)电性拉伸法[63]

Fig.2 Schematic illustration of drawing techniques(a) drawing lithography [56]; (b) droplet-born air blowing [60]; (c) centrifugal lithography [61]; (d) electro-drawing [63]

图3 3D打印法制备聚合物阵列微针的示意图[66]

Fig.3 Schematic illustration of 3D printing method [66]

图4 聚合物阵列微针用于肿瘤治疗的示意图[68]

Fig.4 Schematic illustration of polymeric microneedle arrays used for tumor therapy [68]

图5 聚合物阵列微针用于糖尿病治疗的示意图[80]

Fig.5 Schematic illustration of polymeric microneedle arrays used for diabetes therapy [80]

图6 聚合物阵列微针用于疫苗接种的示意图[85]

Fig.6 Schematic illustration of polymeric microneedle arrays used for vaccination [85]

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