Abstract: In order to afford an insight into the problem of bubble mass transfer,this paper experimentally and theoretically deals with the effective factors of near-interfacial mass transfer of a single bubble.The micro real-time holographic interference results showed that near-interfacial concentration is a stable value of dynamic mass transfer.It was affected by relative velocity,bubble dianmeter,temperature,pressure,etc.The thermodynamic analysis of the bubble mass transfer got the same result as experiment.Nunerical simulation of the near-interfacial concentration field of a single CO_2 bubble absorbed in alcohol was made.