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WANG Shaoting; YANG Zhisheng; ZHU Shanxian
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王绍亭; 杨志生; 朱云仙
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Abstract: A refined double integral method has been applied to the problem encountered in the diffu-sion release of a drug from a polymeric matrix.The finite external mass transfer resistance has alsobeen incorporated into the present analysis.Experimental release rates of 5-fluorouracil fromethylene-vinyl alcohol copolymer into distilled water were measured in order to test the applicabilityof these models.All system parameters were measured by experiments and models were built up.Themodels presented here are much more accurate than Higuchi model and much easier than the exactsolutions.In view of accuracy,the models are almost the same as the exact solutions.The experi-mental release data agree Well with the computed results
Key words: diffusional controlled release, ethylene-vinyl alcohol copolymer, release kinetics
摘要: A refined double integral method has been applied to the problem encountered in the diffu-sion release of a drug from a polymeric matrix.The finite external mass transfer resistance has alsobeen incorporated into the present analysis.Experimental release rates of 5-fluorouracil fromethylene-vinyl alcohol copolymer into distilled water were measured in order to test the applicabilityof these models.All system parameters were measured by experiments and models were built up.Themodels presented here are much more accurate than Higuchi model and much easier than the exactsolutions.In view of accuracy,the models are almost the same as the exact solutions.The experi-mental release data agree Well with the computed results
关键词: diffusional controlled release;ethylene-vinyl alcohol copolymer;release kinetics
WANG Shaoting, YANG Zhisheng, ZHU Shanxian. KINETICS OF DIFFUSION-CONTROLLED DRUG MATRICES RELEASE SYSTEM[J]. .
王绍亭, 杨志生, 朱云仙. KINETICS OF DIFFUSION-CONTROLLED DRUG MATRICES RELEASE SYSTEM[J]. CIESC Journal.
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