Abstract: An adsorption dynamics model for large biomolecules is devloped by using RSA LRS theory The calculated values are obtained by orthogonal collocation method(OCM) The special features as large molecules and biological activity are considered during set up of mathematical model The predicted results are in good agreement with experimental data It is indicated that the mathematical model is suitable for the mass tranfer of LDL and VLDL The simulation computation can be used for designing,operation and optimizing the adsoption system in clinical treatment

摘要： 采用RSA -LRS理论建立起适用于生物大分子的吸附预测模型 ,并用正交配置法获得了模型方程的数值解 .由于模型建立过程中系统地考虑了体系的大分子特性及生物特性 ,使得计算结果与实验测定值相吻合 ,表明适用于描述类似于LDL及VLDL这类蛋白质生物大分子的吸附过程 .模拟计算结果对高效吸附剂的制备、临床操作的控制和最优化具有理论指导作用 .