Abstract: The reactive precipitation process of procaine benzylpenicillin is reviewed, while
suchsecondary processes as ageing, agglomeration, breakage, and the effects of
operationparameters oncrystal size are emphasized. In the reactive precipitation the ageing
of particles has a little effectonthe process, while the greater effect comes fromthe
agglomeration and breakage of particles, furthermore, the mixinghas also notable influence
on the product size. All of these providethe bases for further study onreactive
precipitation.

Key words: procaine benzylpenicillin, reactive precipitation, secondary processes, mixingminipage

摘要： The reactive precipitation process of procaine benzylpenicillin is reviewed, while
suchsecondary processes as ageing, agglomeration, breakage, and the effects of
operationparameters oncrystal size are emphasized. In the reactive precipitation the ageing
of particles has a little effectonthe process, while the greater effect comes fromthe
agglomeration and breakage of particles, furthermore, the mixinghas also notable influence
on the product size. All of these providethe bases for further study onreactive
precipitation.

关键词: procaine benzylpenicillin;reactive precipitation;secondary processes;mixingminipage