Abstract: Mannich reaction of a series of aldehydes, ketones and amines catalyzed by Bronsted acid ionic liquids (ILs) was investigated.1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF₄) /1-butyl-3- methylimidazolium dihydrogen phosphate (BMImH₂PO₄) and 1-ethylimidazolium trifluoroacetic acid (HEImTA) were chosen as reaction media.Shorter reaction time and the excellent yield were obtained as compared with the traditional processes.Product isolation was easy (by hydrolysis of reaction mixture and subsequent filtration), and the acid ionic liquids (also acting as a catalyst) could be easily to be recycled efficiently.The application scope of the established process was also discussed.

摘要： 研究了Bronsted酸离子液体催化下醛、酮、胺的三组分Mannich反应. 在所选取的离子液体体系3-丁基-1-甲基咪唑四氟硼酸盐(BMImBF₄)/3-丁基-1-甲基咪唑磷酸二氢盐(BMImH₂PO₄)及1-乙基咪唑三氟乙酸盐(HEImTA)中，不需要加入酸性催化剂，在室温(25 ℃)下即可高收率和高选择性地得到Mannich产物.离子液体体系经过简单的处理即可实现回收利用.对于上述体系所适用的反应底物范围亦进行了探讨.