Abstract: The effects of different matrix material contents on the release of soluble drug’s mixed matrix were studied.With dissolution as guideline,and Captopril as model drug the effect of matrix material contents on the release of Captopril from hydrophilic gel matrix, wax matrix and mixed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matrix. Moreover, the effect of Compritol 888 contents was more significant than that of HPMC K4M in mixed matrix.

Key words: 卡托普利, 混合骨架片, 体外释放度, 蜡质888

关键词: 卡托普利, 混合骨架片, 体外释放度, 蜡质888