Abstract: The performance of wire gauze structured packing was studied in a packed column of 19 mm internal diameter under the condition of total reflux and high pressure.The pressure ranged from 0.7 MPa to 1.9 MPa. i-Butane/n-butane was used as the testing system.The influence of pressure on HETP was investigated.With the increase of F-factor, the HETP values would slightly decrease at all testing pressure before flooding point.By comparing with the previous experimental data at Tianjin University, it was found that the separation efficiency of wire gauze packing was obviously higher than Mellapak 250Y structured packing.