Abstract: The microcapsule of methyl salicylate（MS）was prepared by utilizing dried yeast(S. cerevisiae)cell deactivated by pretreating as wall material. The effects of encapsulating temperature,MS to yeast ratio and encapsulating time on the microencapsulation of MS were investigated. The results showed that the yield of encapsulated MS could reach 48.58% under the conditions of encapsulating temperature of 70℃,MS to yeast ratio of 2 ml•g^-1 and encapsulating time of 6 h. By means of the novel pharmaceutical microencapsulation, the process was simple and efficient and was free from contamination by organic solvent.

摘要： 以灭活的干酵母细胞为囊壁材料制备水杨酸甲酯微囊.研究了包埋温度、心材比、包埋时间等因素对微囊制备效果的影响.实验结果表明，在包埋温度70℃ 、心材比2 ml•g^-1、包埋时间6 h条件下，水杨酸甲酯包埋率可以达到48.58%.这种新型的药物微囊化方法，具有制备过程简单、包埋率高、不引入有机溶剂的特点.