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戴立言 方俊 王晓钟 陈英奇
Abstract: The preparation of a series of 2-pyridinamines and their alkyl derivatives is described.The target compounds are synthesized starting from corresponding 2-cyanopyridines, via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alkaline mixture of acetone-2% sodium hydroxide solution, and Hoffmann degradation reaction with freshly made NaBrO.This route is of industrial value because of cheap and readily available materials, moderate reaction conditions and convenient operations.
摘要: 本文研究2-氨基吡啶及其衍生物的合成。目标产物以氰基吡啶为原料,以水和丙酮为混合溶剂,在稀碱溶液中,以过氧化氢为催化剂进行不完全水解,然后用新制的次溴酸钠进行霍夫曼降解反应制得。此合成路线周期简短,原料廉价易得,工艺操作简便,反应条件温和,具有较高的工业应用价值。
. Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines[J]. .
戴立言 方俊 王晓钟 陈英奇. 由2-氰基吡啶合成2-氨基吡啶及其烷基衍生物 [J]. CIESC Journal.
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https://hgxb.cip.com.cn/EN/Y2007/V58/I3/670