Abstract: The objective of the study was to derive optimum conditions for preparing crosslinked starch microspheres (ASM). The response surface methodology was used to analyze the effects of dosage of crosslinking agent，reaction temperature and initiator concentration on the yield and average particle size of ASM. The prediction models were also established. Variance analysis revealed that dosage of crosslinking agent，reaction temperature and initiator concentration significantly affected the yield and average particle size of ASM. Optimum conditions obtained were mass fraction of crosslinking agent 0.5%，reaction temperature 48 ℃ and initiator concentration 3.7 mmol/L.The yield and average particle size of ASM under optimized conditions predicted by the models were 77.5% and 16.5 μm respectively. These values were experimentally verified，and good agreement between experimental and predicted values was obtained.

摘要： 为了优化反相悬浮法合成N, N′-亚甲基双丙烯酰胺交联淀粉微球（ASM）的工艺，采用响应曲面法（RSM）分析了交联剂质量分数、反应温度和引发剂浓度对于ASM品质（产率与平均粒径）的影响，并建立了相应的预测模型。方差分析的结果表明：交联剂质量分数、反应温度和引发剂浓度对于ASM产率和平均粒径这两项指标都有着极为显著的影响。通过重叠等高线图确定较优的工艺参数为：交联剂质量分数为0.5%，交联温度为48 ℃，引发剂的物质的量浓度为3.7 mmol/L。对应的ASM产率和平均粒径的预测值分别为：77.5%和16.5 μm。经实验证明：应用响应曲面法所得到的ASM合成工艺参数是可行的。