Abstract: The pretreatment process of propionic acid fermented broth by hollow-fiber membrane was investigated. Different kinds of hollow-fiber membranes were screened，and the separation conditions were optimized. It was shown that the polyvinylidenefluoride microporous hollow-fiber membrane (0.1 μm pore size) was more suitable for this system. When the initial pressure was 0.04 MPa，the absorbance of cell density at 660 nm was less than 0.4，pH value was 6.0 and temperature was 30 ℃，the fermented broth could be better pretreated by this PVDF membrane and an expected result was obtained.

摘要： 利用中空纤维膜对丙酸发酵液的预处理进行了初步研究。对不同型号的中空纤维膜进行了筛选，并对分离条件进行了优化。结果表明：在所考察的膜组件中，孔径为0.1 μm的聚偏氟乙烯（PVDF）微滤膜最适合丙酸发酵体系；在初始压差0.04 MPa、发酵液OD660 nm小于0.4、pH值6.0左右以及温度30 ℃的优化条件下，中空纤维膜能够较好地实现对丙酸发酵液的预处理。