CIESC Journal ›› 2008, Vol. 59 ›› Issue (10): 2531-2535.
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FU Jie; Lv Xiuyang
Online:
Published:
傅杰;吕秀阳
Abstract:
Adenine is an important chemical material widely used in the fields of medicine, organic synthesis and so onPresently, adenine is produced from the condensation of diethyl malonate with formamide, which has serious pollution problemsTo achieve the green production of adenine, noncatalyzed hydrolysis of adenosine in high temperature liquid water was carried outThe effects of initial concentration, agitating speed and temperature on adenosine hydrolysis were studied and the kinetics of adenosine hydrolysis was investigated at temperatures from 150℃ to 190℃Rate constants were evaluated with the zeroth-order reaction assumption and the activation energy was 134.1 kJ·mol-1The experimental results demonstrated that high selective preparation of adenine by non-catalyzed hydrolysis of adenosine in high temperature liquid water was possible.
Key words: 腺苷, 无催化水解, 腺嘌呤, 高温液态水
腺苷,
摘要: 腺嘌呤作为一种重要的化工原料,已广泛应用于医药、有机合成等领域,目前腺嘌呤采用丙二酸二乙酯与甲酰胺缩合反应合成,环境污染较大。为实现腺嘌呤生产的绿色化,同时探索腺苷中C-N断裂的机理,开展了在高温液态水中无催化腺苷水解反应的研究,考察了高温液态水中初始浓度、搅拌速率、温度对腺苷水解的影响,研究了150~190 ℃下腺苷的水解反应动力学,在假设反应为零级反应的情况下拟合得到了各温度的反应速率常数,并得出活化能为174.1 kJ8226;mol-1。实验结果表明,高温水解中腺苷无催化水解制备腺嘌呤是可行的,而且产率较高。
关键词: 腺苷, 无催化水解, 腺嘌呤, 高温液态水
FU Jie, Lv Xiuyang. Kinetics of non-catalyzed hydrolysis of adenosine in high temperature liquid water[J]. CIESC Journal, 2008, 59(10): 2531-2535.
傅杰, 吕秀阳. 高温液态水中腺苷无催化水解反应动力学 [J]. 化工学报, 2008, 59(10): 2531-2535.
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