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GUI Houying,ZHOU Qiuming,HU Xinming,DONG Liuyu
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桂厚瑛,周秋名,胡新明,董留玉
Abstract:
2-Ethylhexyl p-dimethylamiobenzoate was synthesized with higher yield,lower cost and nontoxicity,which is easier realized for large-scale industrial production. Dimethylamino benzoic acid and isooctanol were used as starting materials without any solvent by using p-toluenesulfonic acid as a esterification catalyst. The reaction proceeded as much as possible to remove the produced water under highly reduced pressure,and the reaction temperature was controlled in a range between 110℃and 120℃. The reaction conditions of the esterification without solvent should be emphasized that the temperature was between 110 and 120 ℃ at a negative pressure of 0.095 MPa for 6h. The molar ratio of dimethyl-aminobenzoic acid with isooctanol was 1∶3.5. 2-Ethylhexyl p-dimethylamiobenzoate yield was higher than 90% based ondimethyl-aminobenzoic acid.
摘要:
对合成对二甲氨基苯甲酸异辛酯的原始工艺进行了改进,获得了收率高、成本低、毒性小、污染少的合成工艺优化方法;可实现大规模工业生产。即以N,N-二甲基对氨基苯甲酸和异辛醇为原料,无需溶剂脱水,用对甲苯磺酸作为酯化催化剂,采用高负压的方法除去反应过程中生成的水,从而使正反应能够最大限度地进行,反应温度控制在110~120 ℃。重点讨论了无溶剂参与的酯化反应条件:反应温度110~120 ℃,真空度-0.095 MPa,反应时间6 h,对二甲氨基苯甲酸与异辛醇的摩尔比为1∶3.5,以对二甲氨基苯甲酸计,产品收率为90%。
GUI Houying,ZHOU Qiuming,HU Xinming,DONG Liuyu. Synthesis of 2-ethylhexyl p-dimethylamiobenzoate[J]. .
桂厚瑛,周秋名,胡新明,董留玉. 对二甲氨基苯甲酸异辛酯的合成工艺 [J]. CIESC Journal.
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https://hgxb.cip.com.cn/EN/Y2010/V29/I11/2149