Abstract:

Extractive distillation of pharmaceutical waste water containing tetrahydrofuran，methanol was simulated with the ChemCAD software. Glycol was chosen as extractant，and a process with three towers was designed for seperating the mixture. Extractive distillation of tetrahydrofuran separation from the mixture of tetrahydrofuran，methanol and water was modeled with a tower with 24 theoretical plates，the modulate result indicated that tetrahydrofuran recovery could be up to 99.5% with the conditions as follow. The mixture was fed at the 17th plate at its boiling point，the extractant was fed at the second plate at its boiling point，solvent ratio was 1.65 and reflux ratio was 1.5. The glycol recovery tower needed five plates，and the methanol recovery tower needed eighteen plates. The reliability of the extractive distillation modeling result was verified by experiment.

摘要：

以ChemCAD软件对含有四氢呋喃、甲醇和水的制药废液的萃取精馏分离进行了模拟。以ChemCAD软件确定乙二醇为萃取剂，采用三塔流程分离该混合物。首先模拟以具有24块理论板的精馏塔进行萃取精馏从混合物中分离出四氢呋喃，废液在第17块板以饱和液体进料，萃取剂在第2块板以饱和液体进料，溶剂比采用1.65，回流比为1.5，四氢呋喃回收率可达99.5%。萃取剂乙二醇回收所需塔板数为5块，甲醇回收所需塔板数为18块。通过实验验证了萃取精馏模拟结果的可靠性。