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MAO Yangfan,LI Mingchun,XIN Meihua,XIE Qinqin
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毛扬帆,李明春,辛梅华,谢钦钦
Abstract:
O-quarternary ammonium chitosan bearing carboxymethyl-b-cyclodextrin(QCSCD)was synthesized by grafting carboxymethyl-b-cyclodextrin onto O-quarternary ammonium chitosan in the presence of EDC and NHS. The structure of QCSCD was characterized by FTIR,EA and SEM. Using ketoprofen(KP)as a model drug,the release behavior of QCSCD in mimic gastric and intestinal solutions was investigated in comparison with that of chitosan bearing cyclodextrin(CSCD). Experimental results indicated that QCSCD showed a higher drug-loading capacity with the maximum ketoprofen adsorption of 3.97 mg/mg. Compared with CSCD,QCSCD behaved an opposite pH responsibility and represented more stable release of the entrapped ketoprofen in mimic intestinal solution. These results suggested that QCSCD could be used as a potential biodegradable delivery system for controlled release of hydrophobic drugs with pH-responsive capability.
摘要:
对壳聚糖进行O-季铵化改性,并与羧甲基-β-环糊精在均相条件下进行缩合反应,制得O-季铵化壳聚糖固载环糊精(QCSCD),用FTIR、EA和SEM对产物进行表征。以酮洛芬为模型药物,研究其载药及药物释放行为。结果表明,季铵盐基团的引入提高了QCSCD的载药量,为3.97mg/mg,并且改变了QCSCD的pH响应性能。与壳聚糖固载环糊精相反,QCSCD在模拟胃液中的释放速率很快,而在模拟肠液中具有缓释性能。
MAO Yangfan,LI Mingchun,XIN Meihua,XIE Qinqin. Synthesis of O-quarternary ammonium chitosan bearing cyclodextrin[J]. .
毛扬帆,李明春,辛梅华,谢钦钦. O-季铵化改性壳聚糖固载环糊精的制备及其载药性能 [J]. CIESC Journal.
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https://hgxb.cip.com.cn/EN/Y2010/V29/I9/1705