Abstract:

A new hydrophobic fluorescent polymer containing carbonylhydrazide recognition units（CM-DCS-PyHy）was synthesized by carboxy methylation of N,N-alkylation chitosan（DCS）with chloroacetic acid in the presence of sodium dodecyl sulfonate and then modified by 1-pyrenebutyric acid hydrazide．FTIR，¹H NMR，element analysis and UV-vis were used to characterize the polymer．The polymer had better solubility in organic solvents，such as chloroform，alcohol，tetrahydrofuran etc.，than DCS．Fluorescence spectroscopy indicated concentration dependence of fluorescence of the polymer．The π-A isotherm with lecithin indicated that the polymer with suitable concentration could enhance the stability of lipid monolayer．These suggest the potential use of the polymer in membrane simulation and as a biological detector．

摘要：

制备了N,N-双烷基壳聚糖（DCS），在十二烷基磺酸钠存在下，把羧甲基接枝到DCS的羟基上，再通过酰胺化反应引入1-芘丁酰肼（PyHy）基团，成功地合成了新型油溶性荧光高分子材料N-（O-乙酰基-N,N-双烷基化壳聚糖）-N′-芘丁酰肼（CM-DCS-PyHy）。用FTIR、¹H NMR、EA、固体紫外等手段对产物的结构进行表征。实验结果表明：CM-DCS-PyHy能溶于氯仿、乙醇和四氢呋喃等有机溶剂中，溶解性能优于DCS；CM-DCS-PyHy在氯仿溶液中的荧光光谱具有浓度依赖性；适当浓度的CM-DCS-PyHy能提高磷脂单分子层的稳定性。该材料有望在细胞膜的模拟以及生物探针方面得到应用。