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YIN Shuangqing,JI Min,YAO Risheng
Online:
Published:
尹双青,吉民,姚日生
Abstract:
The stability of coenzyme A solution was studied. It was found that the content of coenzyme A in the solution decreased with increasing storage time and increasing temperature,while it remained relatively constant for 24 h under conditions of temperature 1—5℃ and pH value 4.5. For this reason,the freeze-drying technology was introduced. Using freeze-drying dosage-form and moisture content as qualitative indices,the return warming freeze-drying was proven superior to traditional ladder warming freeze-drying with respect of the product quality of coenzyme A. The characteristics and configuration of coenzyme A obtained from an ordinary drying process and different freeze-drying processes were further analyzed by optical image and X-ray diffraction. The findings demonstrated that the ladder warming freeze-drying process was better than the ordinary drying process with respect to the formation of the crystal structure of coenzyme A,while the return warming freeze-drying process further outweighed the ladder warming freeze-drying process. Moreover,an optimized 16 h return warming freeze-drying process was finally proposed to obtain coenzyme A with high-purity(≥95%),high crystallinity and good stability,based on the research on the return warming freeze-drying process and also the acceleration stability test.
CLC Number:
10. 3969/j. issn. 0438-1157. 2011. 11. 037
YIN Shuangqing,JI Min,YAO Risheng. Freeze-drying process and characteristic configuration of coenzyme A[J]. .
尹双青,吉民,姚日生. 辅酶A的冻干工艺及其性状结构[J]. CIESC Journal.
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