Abstract: Photo-responsive drug delivery systems（Pr-DDS）stands out as a clean and noninvasive DDS. For Pr-DDS，the release of entrapped drugs can be accelerated at a specific location and time upon light-activation，which promotes maximum efficacy. The typical chromophores，incorporated into the photo-responsive drug release systems to render it susceptible to light trigger，include azobenzene（photoisomerization type），spiropyran（formation of zwitterionic species），coumarin（formation of the photo-cross-linking structure），and nitrobenzyl esters（conversion from hydrophobic to hydrophilic block）. In this paper，the progress in Pr-DDS development has been reviewed according to their different chromophores，and their application is also involved. Among these four Pr-DDS，Azo，as the representatives of the photoisomerization type，is the most widely studied one，which involves themicelles，vesicles，hydrogels，liposomes，etc. And nitrobenzyl ester，as the representatives of the conversion from hydrophobic to hydrophilic block type，has attracted wide attention for the two-photon response capability. In conclusion，although great progresses had been made on Pr-DDS，but there were still many problems，including how to improve the biocompatibility，and how to achieve feasible targeted light-controlled release in vivo.

Key words: photo-responsive, azobenzene, spiropyran, coumarin, o-nitrophenyl derivative

摘要： 响应型药物释放体系（Pr-DDS）可以实现药物的定时、定位释放，是一种洁净、无创、高效的载体材料。本文根据为聚合物提供光敏感性的差异性将其分为：光异构化型（偶氮苯，Azo）、分子内光致成键和断裂型（螺吡喃，Spiro）、光二聚化型（香豆素，Cou）以及光致断裂型（邻硝基苯衍生物），并对上述4种类型载体材料的研究进展进行综述。在4类光敏感药物载体材料中，以偶氮苯为代表的光异构化型药物载体研究最为广泛，其中涉及胶团、囊泡、水凝胶、脂质体等，而以邻硝基苯衍生物为代表的光致断裂型由于具有双光子响应能力，近年来也引起了广泛的关注。最后总结指出关于光敏感型药物载体的构建，目前虽取已得了长足的发展，但仍然存在诸多的问题，如何提高生物相容性、增加对目标位置的靶向性以及生物体内光控释放的可行性仍然亟待解决。

关键词: 光响应, 偶氮苯, 螺吡喃, 香豆素, 邻硝基苯衍生物