Abstract: Peracetic acid was prepared as an oxidant from acetic anhydride and H2O2 firstly，and then ε-caprolactone was synthesized by Baeyer-Villiger oxidization of cyclohexanone in a continuous flow micro-channel reactor. The effects of reactants molar ratio，reaction temperature and residence time on reactant conversion and product yield were investigated for both preparation of peracetic acid and synthesis of ε-caprolactone，and the process conditions were optimized. Under conditions of n(acetic anhydride) ∶n(H2O2) = 1.2∶1，reaction temperature at 70℃，residence time of 115s，conversion of H2O2 reached 88.9% and yield of peracetic acid reached 86.7%. Under conditions of n(peracetic acid) ∶n(cyclohexanone) = 1.1∶1，reaction temperature at 90℃，residence time of 90s，conversion of cyclohexanone reached 96.2% and yield of ε-caprolactone reached 80.9%. Comparing with the traditional batch reaction process，the selectivities and yields of target products in this continuous micro-channel reaction process were increased with shortened reaction time and lessened raw material consumption，and process continuity ensured higher operation safety.

Key words: micro-channel reactor, cyclohexanone, ε-caprolactone, Baeyer-Villiger oxidation

摘要： 在微通道反应器中，由H2O2、乙酸酐反应连续合成过氧乙酸氧化剂，再与环己酮经Baeyer-Villiger氧化连续合成ε-己内酯。先后考察了过氧乙酸氧化剂合成中乙酸酐与H2O2摩尔比、反应温度、停留时间等因素的影响，环己酮氧化反应中原料摩尔配比、反应温度、停留时间等因素对ε-己内酯合成的影响，优化了工艺条件。结果表明，当n(乙酸酐)∶n(H2O2)=1.2∶1、反应温度为70℃、停留时间为115s时，H2O2转化率达88.9%，过氧乙酸收率达86.7%；当n(过氧乙酸)∶n(环己酮)=1.1∶1、反应温度为90℃、停留时间为90s时，环己酮转化率达96.2%，ε-己内酯的收率达80.9%。与传统间歇釜式反应工艺相比，微通道反应工艺提高了ε-己内酯的收率和选择性，缩短了反应时间，减少了原料消耗，实现了连续化操作，提高了生产安全性。

关键词: 微通道反应器, 环己酮, ε-己内酯, Baeyer-Villiger氧化