New process for preparing benazepril precursor

Abstract

Abstract:

The present work relates to a new synthesis process for the preparation of 3-（1-ethoxycarbonyl-3-phenylpropyl）-amino］-2，3，4，5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester（EPTAB），the precursor of benazepril HClThe reaction conditions were optimized.The diastereomeric products were separated by flash column chromatography.The structures of the products were characterized with IR and NMR.

Key words: 盐酸贝那普利, EPTAB, 合成

摘要： 本文采用两种过程制备盐酸贝那普利的前体[3-[(1-乙氧羰基-3-苯基丙基)-氨基]-2,3,4,5-四氢-2-氧代-1-H-1-苯并氮杂卓-1-乙酸叔丁酯(EPTAB)，并优化了其制备条件。异构体的分离采用柱层析分离。产品结构采用IR和NMR表征。

关键词: 盐酸贝那普利, EPTAB, 合成

Kafssi Hassan, WANG Tao, WANG Fang, WAN Pingyu. New process for preparing benazepril precursor[J]. CIESC Journal, 2007, 58(10): 2558-2560.

Kafssi Hassan, 王涛, 王芳, 万平玉. 贝那普利前体的制备 [J]. 化工学报, 2007, 58(10): 2558-2560.

[1]	MA Chun’an, CHU Chengpu, XU Yinghua, ZHANG Hong. Synthesis of 3,6-dichloropicolinic acid [J]. , 2011, 62(9): 2398-2405.
[2]	LIU Duo, DU Jin, ZHAO Guangrong, YUAN Yingjin. Applications of synthetic biology in medicine and energy [J]. CIESC Journal, 2011, 62(9): 2391-2397.
[3]	. [J]. CIESC Journal, 2011, 62(6): 1701-1707.
[4]	. [J]. CIESC Journal, 2011, 62(4): 1070-1076.
[5]	HOU Chaopeng，XIA Guofu，LI Mingfeng, NIE Hong, LI Dadong. Thermodynamics of hydrogen sulfide poisoning and feasibility of sulfur tolerance on F-T synthesis catalyst [J]. , 2011, 62(3): 598-603.
[6]	CHENG Wenjing, ZHENG Cheng, MAO Taoyan, SUN Baoxing. Microwave synthesis technique and properties of octadecylmethyldihydroxyethyl ammonium bromide [J]. CIESC Journal, 2011, 62(2): 566-573.
[7]	GAO Yong, YANG Xiaohang, YOU Chuchu, OUYANG Han, YUAN Yaofeng. Synthesis of 5(6)-carboxy-rhodamine 110 [J]. CIESC Journal, 2011, 62(2): 374-377.
[8]	<，<， Effect of styrene-sodium acrylate ionomer/poly(ethylene glycol）on crystallization behavior of PET [J]. , 2011, 62(12): 3569-3574.
[9]	<YANG Zhaopan, SHI Tiejun, TAN Dexin. Synthesis of dipropargyl ether of bisphenol A and thermal degradation kinetics of its polymer [J]. , 2011, 62(12): 3554-3559.
[10]	CAI Lu ，GUO Jianwei，LIU Sa，GUAN Nianyun，ZHU Lejie，CUI Yingde，SUN Baoxing. Synthesis of adamantane-containing cationic surfactants [J]. , 2011, 62(11): 3295-3300.
[11]	MA Chun’an, QIU Zhijun, ZHAO Fengming,ZHU Xiushan, CHU Youqun. Oxygen evolution properties of titanium-based IrO₂+SnO₂ electrode and application in electrolytic synthesis of succinic acid [J]. , 2011, 62(11): 3222-3227.
[12]	DONG Yingying, WEI Gongyuan, ZHANG Junli, CHEN Xuedong. Mechanism and effect of acid stress on glutathione biosynthesis by Candida utilis [J]. , 2011, 62(11): 3228-3235.
[13]	YAN Ping, HU Xiaomin, SUN Xudong. Preparation and sinterability of Ce_0.8Sm_0.2O_1.9 powders by sol-gel and low temperature self-propagating synthesis [J]. CIESC Journal, 2011, 62(1): 262-268.
[14]	GAO Zhihua, JIA Qin, HUANG Wei, YIN Lihua, XIE Kechang. Catalytic performance of CuZnAl slurry catalyst prepared by complete liquid phase technology for direct synthesis DME from syngas [J]. CIESC Journal, 2011, 62(1): 85-91.
[15]	FENG Baicheng，GUAN Xianwen，WANG Guangxin. Application of dimensionally stable anodes in electro-synthesis of adiponitrile [J]. , 2010, 61(S1): 68-71.

New process for preparing benazepril precursor

贝那普利前体的制备

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments