CIESC Journal ›› 2024, Vol. 75 ›› Issue (4): 1153-1166.DOI: 10.11949/0438-1157.20231326

• Reviews and monographs • Previous Articles     Next Articles

Advances in drug nanodelivery systems for the treatment of intracellular bacterial infections

Xiaojie JU(), Wanlu SONG, Chenyu ZHOU, Qiutong SHEN, Yutian LIAO, Jueying GONG, Liangyin CHU   

  1. School of Chemical Engineering, Sichuan University, Chengdu 610065, Sichuan, China
  • Received:2023-12-12 Revised:2024-01-23 Online:2024-06-06 Published:2024-04-25
  • Contact: Xiaojie JU

纳米药物载体用于治疗胞内菌感染的研究进展

巨晓洁(), 宋婉璐, 周宸宇, 沈秋彤, 廖雨田, 龚珏颖, 褚良银   

  1. 四川大学化学工程学院,四川 成都 610065
  • 通讯作者: 巨晓洁
  • 作者简介:巨晓洁(1980—),女,博士,教授,juxiaojie@scu.edu.cn
  • 基金资助:
    国家自然科学基金项目(22078202);四川大学-中国核动力研究设计院联合创新基金项目(JG2022300)

Abstract:

Intracellular bacteria can escape the body's immunity and grow and reproduce normally in the host cell, which are more difficult to remove than extracellular bacteria and can easily cause more serious infections. With traditional antibiotic treatment, the drugs cannot break through the host cell membrane barrier and can easily cause strong toxic side effects and multidrug resistance. Excellent nanocarriers have good biocompatibility and are easy to modify, which is expected to enhance membrane penetration and bacterial targeting of antibacterial drugs through the construction of nanodelivery systems, offering great potential and broad prospects in the treatment of intracellular bacterial infections. This paper introduces various nanoparticles that can be used to treat intracellular bacterial infections, summarizes the mechanisms and methods for enhancing the therapeutic effects of drug nanodelivery systems, and elaborates on the problems that still exist when using nano-drug delivery systems to treat intracellular bacterial infections, in order to provide inspiration for the construction of better drug delivery systems to treat intracellular bacterial infections.

Key words: nanocarriers, intracellular bacteria, bacterial targeting, antibacterial strategy

摘要:

胞内菌能够逃避机体免疫并在宿主细胞内正常生长繁殖,比起胞外细菌更难清除,容易造成较为严重的感染。传统的抗生素治疗,药物无法突破宿主细胞膜的屏障,并且容易引起较强的毒副作用和多药耐药性。优良的纳米载体具有良好的生物相容性且易于修饰,有望通过构建纳米药物递送系统增强抗菌药物的细胞膜穿透性和胞内菌靶向性,在治疗胞内菌感染上具有巨大潜力和广阔前景。介绍了目前可用于治疗胞内菌感染的各种纳米颗粒,归纳总结了增强纳米药物递送系统治疗效果的机制和方法,阐述了目前在使用纳米药物递送系统治疗胞内菌感染时仍存在的问题,以期为构建更优良的纳米药物递送系统治疗胞内菌感染提供启发。

关键词: 纳米载体, 胞内菌, 细菌靶向, 抗菌策略

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