CIESC Journal ›› 2013, Vol. 64 ›› Issue (10): 3493-3504.doi: 10.3969/j.issn.0438-1157.2013.10.002

Previous Articles     Next Articles

Research progress of Zein as carrier for drug delivery systems

LIU Guijin, WANG Hongdi, JIANG Yanbin   

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China
  • Received:2013-03-20 Revised:2013-06-26 Online:2013-10-05 Published:2013-10-05
  • Supported by:

    supported by the National Natural Science Foundation of China(21076084,21276091)and Programs Foundation of Ministry of Education of China(20120172110010).

Abstract: Zein,one of the natural and edible biomacromolecules in plant,is renewable,nontoxic,biocompatible and biodegradable.Zein is capable of self-assembly into microspheres or nanoparticles because of its amphipathicity,and is an attractive drug carrier and has a promising prospect for drug delivery systems(DDS).Recently,the study of using Zein as carrier for drug delivery systems has become popular.The properties and advantages of Zein used as DDS carriers were introduced at first in this paper.Then,methods for the preparation of Zein-DDS and the characteristics of Zein-DDS were reviewed in detail.Moreover,the researches on the modification of Zein for carrier were also presented.In summary,Zein has a strong hydrophobicity and a good resistance to the digestive processes of stomach. Therefore,Zein-DDS can improve the stability of drugs,control and prolong drug release,and enhance drug targeting effectively.The future orientations could focus on broadening research fields,improving preparation methods and developing modification of Zein.

Key words: Zein, self-assembly, drug delivery system, carrier, controlled release, modification

CLC Number: 

  • TQ469

[1] Allen T M,Cullis P R.Drug delivery systems:entering the mainstream[J].Science,2004,303(5665):1818-1822
[2] Folkman J,Long D M.The use of silicone rubber as a carrier for prolonged drug therapy[J].J.Surg.Res.,1964,4 (3):139-142
[3] Soppimath K S,Aminabhavi T M,Kulkarni A R,Rudzinski W E.Biodegradable polymeric nanoparticles as drug delivery devices[J].J.Control.Release,2001,70(1-2):1-20
[4] Elzoghby A O,Samy W M,Elgindy N A.Albumin-based nanoparticles as potential controlled release drug delivery systems[J].J.Control.Release,2012,157(2):168-182
[5] Romero-Cano M S,Vincent B.Controlled release of 4-nitroanisole from poly(lactic acid)nanoparticles[J].J.Control.Release,2002,82(1):127-135
[6] Allémann E,Leroux J C,Gurny R,Doelker E.In vitro extended-release properties of drug-loaded poly(DL-lactic acid)nanoparticles produced by a salting-out procedure[J].Pharm.Res.,1993,10(12):1732-1737
[7] Song C X,Labhasetwar V,Murphy H,Qu X,Humphrey W R,Shebuski R J,Levy R J.Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery[J].J.Control.Release,1997,43(2/3):197-212
[8] Leucuta S E.Controlled release of nifedipine from gelatin microspheres and microcapsules:in vitro kinetics and pharmacokinetics in man[J].J.Microencapsul.,1990,7(2):209-217
[9] Kratz F.Albumin as a drug carrier:design of prodrugs,drug conjugates and nanoparticles[J].J.Control.Release,2008,132(3):171-183
[10] Elzoghby A O,El-Fotoh W S A,Elgindy N A.Casein-based formulations as promising controlled release drug delivery systems[J].J.Control.Release,2011,153(3):206-216
[11] Agnihotri S A,MallikarjunaN N,Aminabhavi T M. Recent advances on chitosan-based micro-and nanoparticles in drug delivery[J].J.Control.Release,2004,100(1):5-28
[12] Hirayama F,Uekama K.Cyclodextrin-based controlled drug release system[J].Adv.Drug Deliver.Rev.,1999,36(1):125-141
[13] Ashford M,Fell J,Attwood D,Sharma H,Woodhe P. Studies on pectin formulations for colonic drug delivery[J].J.Control.Release,1994,30(3):225-232
[14] Elzoghby A O,Samy W M,Elgindy N A.Protein-based nanocarriers as promising drug and gene delivery systems[J].J.Control.Release,2012,161(1):38-49
[15] Reddy N,Yang Y Q.Potential of plant proteins for medical applications[J].Trends Biotechnol.,2011,29(10):490-498
[16] Shukla R,Cheryan M.Zein:the industrial protein from corn[J].Ind.Crop.Prod.,2001,13(3):171-192
[17] Evans C D,Manley R H.Solvents for Zein:primary solvents[J].Ind.Eng.Chem.,1941,33(11):1416-1417
[18] Manley R H,Evans C D.Binary solvents for Zein[J].Ind.Eng.Chem.,1943,35(6):661-665
[19] Evans C D,Manley R H.Ternary solvents for Zein[J].Ind.Eng.Chem.,1944,36(5):408-410
[20] Argos P,Pedersen K,Marks M D,Larkins B A.A structural model for maize Zein proteins[J].J. Biol.Chem.,1982,257(17):9984-9990
[21] Matsushima N,Danno G,Takezawa H,Izumi Y.Three-dimensional structure of maize α-Zein proteins studied by small-angle X-ray scattering[J].Biochim.Biophys.Acta,Protein Struct.Mol.Enzymol.,1997, 1339(1):14-22
[22] Lai H M,Geil P H,Padua G W.X-ray diffraction characterization of the structure of Zein-oleic acid films[J].J.Appl.Polym.Sci.,1999,71(8):1267-1281
[23] Wang Q,Wang J F,Geil P H,Padua G W.Zein adsorption to hydrophilic and hydrophobic surfaces investigated by surface plasmon resonance[J].Biomacromolecules,2004,5(4):1356-1361
[24] Wang Q,Yin L L,Padua G W.Effect of hydrophilic and lipophilic compounds on Zein microstructures[J].Food Biophys.,2008,3(2):174-181
[25] Wang Y,Padua G W.Formation of Zein microphases in ethanol-water[J].Langmuir,2010, 26(15):12897-12901
[26] Wang Y,Padua G W.Nanoscale characterization of Zein self-assembly[J].Langmuir,2012,28(5):2429-2435
[27] Xiao D,Davidson P M,Zhong Q X.Release and antilisterial properties of nisin from Zein capsules spray-dried at different temperatures[J].LWT-Food Sci.Technol.,2011,44(10):1977-1985
[28] Karthikeyan K,Lakra R,Rajaram R,Korrapati P S. Development and characterization of Zein-based micro carrier system for sustained delivery of aceclofenac sodium[J].AAPS PharmSciTech,2012,13(1):143-149
[29] Hu D D,Lin C C,Liu L,Li S N,Zhao Y P.Preparation,characterization,and in vitro release investigation of lutein/Zein nanoparticles via solution enhanced dispersion by supercritical fluids[J].J.Food Eng.,2012,109(3):545-552
[30] Matsuda Y,Suzuki T,Sato E,Sato M,Koizumi S,Unno K,Kato T,Nakai K.Novel preparation of Zein microspheres conjugated with PS-K available for cancer immunotherapy[J].Chem.Pharm.Bull.,1989,37(3):757-759
[31] Suzuki T,Sato E,Matsuda Y,Tada H,Unno K,Kato T.Preparation of Zein microspheres conjugated with antitumor drugs available for selective cancer chemotherapy and development of a simple colorimetric determination of drugs in microspheres[J].Chem.Pharm.Bull.,1989,37(4):1051-1054
[32] Liu X M,Sun Q S,Wang H J,Zhang L,Wang J Y.Microspheres of corn protein,Zein,for an ivermectin drug delivery system[J].Biomaterials,2005,26(1):109-115
[33] Lai L F,Guo H X.Preparation of new 5-fluorouracil-loaded Zein nanoparticles for liver targeting[J].Int.J.Pharm.,2011, 404(1/2):317-323
[34] Muthuselvi L,Dhathathreyan A.Simple coacervates of Zein to encapsulate Gitoxin[J].Colloids Surf.,B,2006,51(1):39-43
[35] Fu J X,Wang H J,Zhou Y Q,Wang J Y.Antibacterial activity of ciprofloxacin-loaded Zein microsphere films[J].Mater.Sci.Eng.,C,2009,29(4):1161-1166
[36] Lau E T L,Johnson S K,Mikkelsen D,Halley P J,Steadman K J.Preparation and in vitro release of Zein microparticles loaded with prednisolone for oral delivery[J].J.Microencapsul.,2012,29(7):706-712
[37] Hurtado-López P,Murdan S.Formulation and characterisation of Zein microspheres as delivery vehicles[J].J.Drug Del.Sci.Tech.,2005,15(4):267-272
[38] Patel A,Hu Y C,Tiwari J K,Velikov K P.Synthesis and characterisation of Zein-curcumin colloidal particles[J].Soft Matter,2010,6(24):6192-6199
[39] Wu Y P,Luo Y G,Wang Q.Antioxidant and antimicrobial properties of essential oils encapsulated in Zein nanoparticles prepared by liquid-liquid dispersion method[J].LWT-Food Sci.Technol.,2012,48(2):283-290
[40] Zou T,Li Z,Percival S S,Bonard S,Gu L W. Fabrication,characterization,and cytotoxicity evaluation of cranberry procyanidins-Zein nanoparticles[J].Food Hydrocolloid.,2012,27(2):293-300
[41] Demchak R J.Process for making avermectin/Zein compositions[P]:US,5436355.1995-07-25
[42] Demchak R J,Dybas R A.Photostability of abamectin/Zein microspheres[J].J.Agr.Food Chem.,1997,45(1):260-262
[43] Zhong Q X,Jin M F.Nanoscalar structures of spray-dried Zein microcapsules and in vitro release kinetics of the encapsulated lysozyme as affected by formulations[J].J.Agr.Food Chem.,2009,57(9):3886-3894
[44] Quispe-Condori S,Saldaa M D A,Temelli F. Microencapsulation of flax oil with Zein using spray and freeze drying[J].LWT-Food Sci.Technol.,2011,44(9):1880-1887
[45] Zhong Q X,Jin M F,Davidson M,Zivanovic S.Sustained release of lysozyme from Zein microcapsules produced by a supercritical anti-solvent process[J].Food Chem.,2009,115(2):697-700
[46] Sun Lijun(孙丽君),Shen Peiqiong(沈佩琼),Zhao Yaping(赵亚平).Preparation of resveratro-loaded Zein nanoparticles by method of supercritical CO2 anti-solvent technology[J].Fine Chemicals(精细化工),2011,28(3):270-274
[47] Sun Lijun(孙丽君),Lin Changchun(林长春),Zhao Xiangyu(赵翔宇),Zhao Yaping(赵亚平).Optimizing supercritical anti-solvent preparation of β-carotene-loaded Zein nanospheres by response surface methodology[J].Food Science(食品科学),2011,32(8):19-23
[48] Jiang Y B,Sun W L,Wang W.Recrystallization and micronization of 10-hydroxycamptothecin by supercritical antisolvent process[J].Ind.Eng.Chem.Res.,2012,51(6):2596-2602
[49] Wang W,Liu G J,Wu J,Jiang Y B.Co-precipitation of 10-hydroxycamptothecin and poly(L-lactic acid)by supercritical CO2 anti-solvent process using dichloromethane/ethanol co-solvent[J].J. Supercrit. Fluids,2013,74:137-144
[50] Li W F,Liu G J,Li L X,Wu J,Lü Y X,Jiang Y B.Effect of process parameters on co-precipitation of paclitaxel and poly(L-lactic acid)by supercritical antisolvent process[J].Chinese J.Chem.Eng.,2012,20(4):803-813
[51] Gomez-Estaca J,Balaguer M P,Gavara R,Hernandez-Munoz P.Formation of Zein nanoparticles by electrohydrodynamic atomization:effect of the main processing variables and suitability for encapsulating the food coloring and active ingredient curcumin[J].Food Hydrocolloid.,2012,28(1):82-91
[52] Patel A R,Bouwens E C,Velikov K P.Sodium caseinate stabilized Zein colloidal particles[J].J.Agric.Food Chem.,2010,58(23):12497-12503
[53] Podaralla S,Perumal O.Preparation of Zein nanoparticles by pH controlled nanoprecipitation method[J].J. Biomed.Nanotechnol.,2010,6(4):312-317
[54] Podaralla S,Perumal O.Influence of formulation factors on the preparation of Zein nanoparticles[J].AAPS PharmSciTech,2012, 13(3):919-927
[55] Ariyoshi Y.Angiotensin-converting enzyme inhibitors derived from food proteins[J].Trends Food Sci. Technol.,1993, 4(5):139-144
[56] Hurtado-Lopez P,Murdan S.Zein microspheres as drug/antigen carriers:a study of their degradation and erosion,in the presence and absence of enzymes[J].J.Microencapsul.,2006,23(3):303-314
[57] Dong J,Sun Q,Wang J Y.Basic study of corn protein,Zein,as a biomaterial in tissue engineering,surface morphology and biocompatibility[J].Biomaterials,2004,25(19):4691-4697
[58] Park H J,Bunn J M,Weller C L,Vergano P J,Testin R F.Water vapor permeability and mechanical properties of grain protein-based films as effected by mixtures of polyethylene glycol and glycerin plasticizers[J].Trans. ASAE.,1994,37(4):1281-1285
[59] Mangala T,Allan J E.Modification of Zein films by incorporation of poly(ethylene glycol)s[J].Polym.Int.,2000, 49(1):127-134
[60] Paramawati R,Yoshino T,Isobe S.Properties of plasticized-Zein film as affected by plasticizer treatments[J].Food Sci.Technol.Res.,2001,7(3):191-194
[61] Lai H M,Padua G W,Wei L S.Properties and microstructure of Zein sheets plasticized with palmitic and stearic acids[J].Cereal Chem.,1997,74(1):83-90
[62] Wu Leiyan(吴磊燕),Wen Qibiao(温其标),Yang Xiaoquan(杨晓泉).Effect of plasticizer on surface and mechanical properties of Zein films[J].CIESC Journal(化工学报),2010,61(1):137-145
[63] Wu Q X,Yoshino T,Sakabe H,Zhang H K,Isobe S. Chemical modification of Zein by bifunctional polycaprolactone(PCL)[J].Polymer,2003, 44(14):3909-3919
[64] Sessa D J,Cheng H N,Kim S,Selling G W,Biswas A.Zein-based polymers formed by modifications with isocyanates[J].Ind.Crop.Prod.,2013,43:106-113
[65] Kim S,Sessa D J,Lawton J W.Characterization of Zein modified with a mild cross-linking agent[J].Ind. Crop.Prod.,2004,20(3):291-300
[66] Podaralla S,Averineni R,Alqahtani M,Perumal O.Synthesis of novel biodegradable methoxy poly(ethylene glycol)-Zein micelles for effective delivery of curcumin[J].Mol.Pharm.,2012,9(9):2778-2786
[67] Müller V,Piai J F,Fajardo A R,Fávaro S L,Rubira A F,Muniz E C,et al.Preparation and characterization of Zein and Zein-chitosan microspheres with great prospective of application in controlled drug release[J].J. Nanomater.,2011,2011(1):1-6
[68] Luo Y C,Zhang B C,Cheng W H,Wang Q.Preparation,characterization and evaluation of selenite-loaded chitosan/TPP nanoparticles with or without Zein coating[J].Carbohyd.Polym.,2010,82(3):942-951
[69] Luo Y C,Zhang B C,Whent M,Yu L L,Wang Q. Preparation and characterization of Zein/chitosan complex for encapsulation of α-tocopherol,and its in vitro controlled release study[J].Colloids Surf.,B,2011,85(2):145-152
[70] Luo Y,Teng Z,Wang Q.Development of Zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3[J].J.Agr.Food Chem.,2012,60(3):836-843
[71] Liu L S,Fishman M L,Hicks K B,Kende M,Ruthel G.Pectin/Zein beads for potential colon-specific drug delivery:synthesis and in vitro evaluation[J].Drug Deliv.,2006,13(6):417-423
[72] Mukhidinov Z K,Kasimova G F,Bobokalonov D T,Bobokalonov,Khalikov D Kh,Teshaev Kh I,Khalikova M D,Liu L-S.Pectin-zein microspheres as drug delivery systems[J].Pharm.Chem.J.,2011,44(10):564-568
[73] Alcntara A C S,Aranda P,Darder M,Ruiz-Hitzky E.Bionanocomposites based on alginate-zein/layered double hydroxide materials as drug delivery systems[J].J.Mater.Chem.,2010,20(42):9495-9504
[74] Xu H,Jiang Q,Reddy N,Yang Y.Hollow nanoparticles from Zein for potential medical applications[J].J.Mater.Chem.,2011,21(45):18227-18235
[75] Regier M C,Taylor J D,Borcyk T,Yang Y,Pannier A K.Fabrication and characterization of DNA-loaded Zein nanospheres[J].J.Nanobiotechnol.,2012,10(1):44
[76] Aswathy R G,Sivakumar B,Brahatheeswaran D,Fukuda T,Yoshida Y,Maekawa T,Kumar D S.Biocompatible fluorescent zein nanoparticles for simultaneous bioimaging and drug delivery application[J].Adv.Nat.Sci.,2012,3(2):025006
[1] Yuming ZHANG, Lifeng WAN, Juntao GUAN, Haipeng SONG, Hang YANG, Shiqiu GAO. Fundamental study on the fluid coking behavior of Dagang oil slurry and preparation of aromatic-rich oil [J]. CIESC Journal, 2021, 72(8): 4325-4335.
[2] Xinbin NIE, Dehao ZHANG, Weicheng YAN. Research progress of functional microbubble materials [J]. CIESC Journal, 2021, 72(8): 3984-3996.
[3] Linzhou ZHAO, Yan'e ZHENG, Kongzhai Li, Yaming WANG, Lihong JIANG, Haoxi FAN, Yajing WANG, Xing ZHU, Yonggang WEI. Application of Ce1-xNixOy oxygen carriers in chemical-looping reforming of methane coupled with CO2 reduction [J]. CIESC Journal, 2021, 72(8): 4371-4380.
[4] ZHANG Zhihua, DU Wei, DUAN Xuezhi, ZHOU Xinggui. Au nanoparticles immobilized on surface modified TS-1-B as high-efficiency bifunctional catalyst for propylene epoxidation with H2 and O2 [J]. CIESC Journal, 2021, 72(7): 3613-3625.
[5] LIU Jiawei, HAO Yufeng, SU Yanlei. Biomimetic modification and stability of graphene quantum dots nanofiltration membranes [J]. CIESC Journal, 2021, 72(6): 3390-3398.
[6] LIANG Xingtang, LI Fengzhi, ZHONG Shuming, ZHANG Ruirui, JIAO Shufei, WANG Shuangshuang, YIN Yanzhen. In-situ modification of porous juncus with polyethyleneimine for efficient capture of Cr(Ⅵ) from wastewater [J]. CIESC Journal, 2021, 72(6): 3380-3389.
[7] XIN Mudi, XING Enhui. Researches on trimethylphosphine and metal oxide modification on ZSM-5 and their influence on catalytic cracking [J]. CIESC Journal, 2021, 72(5): 2657-2668.
[8] YANG Lin, MENG Xiaomi, YAO Lu, LAI Yuguo, JIANG Wenju. Combined low-temperature flue gas denitrification and desulfurization over the natural mineral blending modified activated coke [J]. CIESC Journal, 2021, 72(4): 2241-2248.
[9] ZHOU Ye, XIAO Huixia, WANG Yifei, YU Guangsuo. Study on improving slurryability of lignite based on coal blending and surface modification [J]. CIESC Journal, 2021, 72(4): 2233-2240.
[10] WANG Liming, DU Miao, SHAN Guorong, LU Qing, SONG Yihu. Research progress of rubber composite with low dynamic heat generation [J]. CIESC Journal, 2021, 72(2): 863-875.
[11] HE Pengpeng, ZHAO Song, MAO Chenyue, WANG Zhi, WANG Jixiao. Research progress of solvent-resistant composite nanofiltration membrane [J]. CIESC Journal, 2021, 72(2): 727-747.
[12] SHI Pan, YAN Xiaoxiao, WANG Xingzheng, FENG Leyun, CHEN Dong. One-step fabrication of biocompatible oil-core microcapsules with controlled release [J]. CIESC Journal, 2021, 72(1): 619-627.
[13] Danyang SUN, Tingting ZHAI, Hansheng LI, Wenfang LIU. Research progress on modification strategy of g-C3N4 and g-C3N4/Ti3C2 heterojunction [J]. CIESC Journal, 2020, 71(S2): 1-11.
[14] Junyuan WU, Weizhi HUO, Zhiqiang LI, Jiaheng ZENG, Yanbin JIANG. Preparation of coaxial electrospun zein nanofiber film embedding sodium lignosulfonate for enhanced adsorption of heavy metal ions [J]. CIESC Journal, 2020, 71(S1): 252-260.
[15] Zhiqiang LI, Na LYU, Lanying JIANG. Modification of commercial forward osmosis membranes and investigation on treatment of coking wastewater [J]. CIESC Journal, 2020, 71(S1): 461-470.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] LIANG Jun, QIAN Jixin. Multivariate Statistical Process Monitoring and Control: Recent Developments and
Applications to Chemical Industry
[J]. , 2003, 11(2): 191 -203 .
[2] DIAO Yanhua, ZHAO Yaohua, WANG Qiuliang. Visualization of Bubble Dynamics for Pool Boiling of Binary Refrig-erant Mixture R11-R113[J]. , 2006, 14(2): 149 -157 .
[3] LI Cuiqing, SUN Guida, LI Chengyue, SONG Yajuan. Preparation, Characterization, Hydrodesulfurization and Hydrode-nitrogenation Activities of Alumina-supported Tungsten Phosphide Catalysts[J]. , 2006, 14(2): 184 -193 .
[4] LIANG Xuezheng, GAO Shan, WANG Wenjuan, CHENG Wenping, YANG Jianguo. Ketalization of Catechol with Carbonyl Compounds Catalyzed by Metal p-Toluenesulfonate as Biphasic Acid Catalyst[J]. , 2008, 16(1): 124 -127 .
[5] GU Hanyang, GUO Liejin. Experimental Investigation of Slug Development on Horizontal Two-phase Flow[J]. , 2008, 16(2): 171 -177 .
[6] LIU Yiping, ZHANG Hua, WANG Shuhua, WANG Jing. Prediction of Pressure Gradient and Holdup in Small Eötvös Number Liquid-Liquid Segregated Flow[J]. , 2008, 16(2): 184 -191 .
[7] LI Xiang, LI Zhong, LUO Ling'ai. Adsorption Kinetics of Dibenzofuran in Activated Carbon Packed Bed[J]. , 2008, 16(2): 203 -208 .
[8] WU Yanling, LU Jiangang, SUN Youxian. An Improved Differential Evolution for Optimization of Chemical Process[J]. , 2008, 16(2): 228 -234 .
[9] FANG Lide, ZHANG Tao. Performance of a Horizontally Mounted Venturi in Low-pressure Wet Gas Flow[J]. , 2008, 16(2): 320 -324 .
[10] GENG Yanfang, WANG Tengfang, YU Dahong, PENG Changjun, LIU Honglai, HU Ying. Densities and Viscosities of the Ionic Liquid[C4mim][PF6]+N,N-dimethylformamide Binary Mixtures at 293.15 K to 318.15 K[J]. , 2008, 16(2): 256 -262 .