Autocatalytic kinetics of cefodizime sodium solvate in crystallization

doi:10.3969/j.issn.0438-1157.2013.02.020

CIESC Journal ›› 2013, Vol. 64 ›› Issue (2): 555-560.DOI: 10.3969/j.issn.0438-1157.2013.02.020

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Autocatalytic kinetics of cefodizime sodium solvate in crystallization

ZHANG Xinwei^1,2, YIN Qiuxiang¹, LIU Zengkun¹, GONG Junbo¹

1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2. Fushun Research Institute of Petroleum and Petrochemicals, SINOPEC, Fushun 113001, Liaoning, China

Received:2012-08-24 Revised:2012-12-04 Online:2013-02-05 Published:2013-02-05
Supported by:
supported by the National Natural Science Foundation of China (20836005, 21176173),Tianjin Municipal Natural Science Foundation (10JCYBJC14200,11JCZDJC20700) and the State Key Laboratory of Chemical Engineering (SKL-ChE-11B02).

头孢地嗪钠溶剂化物结晶过程自催化动力学

张信伟^1,2, 尹秋响¹, 刘增坤¹, 龚俊波¹

1. 天津大学化工学院,化学工程联合国家重点实验室,天津 300072;
2. 中国石油化工股份有限公司抚顺石油化工研究院,辽宁抚顺 113001

通讯作者: 龚俊波
作者简介:张信伟(1982—),男,博士研究生。
基金资助:
国家自然科学基金项目(20836005,21176173);天津市自然科学基金项目(10JCYBJC14200,11JCZDJC20700);化学工程联合国家重点实验室开放课题项目(SKL-ChE-11B02)。

Abstract

Abstract: The analysis on the crystallization of cefodizime sodium solvate shows that the conversion-time curve presents three characteristics:S-shape, the turning-point, and the turning-point corresponding to the maximum crystallization rate.Therefore, the crystallization of cefodizime sodium solvate could be assumed as an autocatalytic process, and the Prout-Tompkins model was modified according to the solubility curve in order to apply in solution crystallization.The autocatalytic kinetics of solvate crystallization was studied at different temperatures and initial concentrations.The effect of temperature was explained from two aspects:thermodynamics and nucleation mechanism.The kinetic parameters (activation energy E and pre-exponential factor k) of the autocatalytic kinetic models were estimated by multiple linear regression method.

Key words: cefodizime sodium, solvate, crystallization, Prout-Tompkins model, autocatalytic kinetics

摘要： 采用在线拉曼光谱在不同结晶温度和溶液初始浓度的条件下,研究了头孢地嗪钠溶剂化物结晶过程的动力学行为,从热力学和成核机理的角度分析了温度和初始浓度对动力学的影响。根据动力学曲线的特征,将头孢地嗪钠溶剂化物的结晶过程假定为"自催化"过程。针对头孢地嗪钠溶剂化物结晶过程的特殊性,修正了Prout-Tompkins模型;并通过不同温度下的动力学数据,采用多元线性回归拟合了头孢地嗪钠溶剂化物结晶过程的自催化动力学模型参数E和k。

关键词: 头孢地嗪钠, 溶剂化物, 结晶, Prout-Tompkins模型, 自催化动力学

CLC Number:

TQ032.4

ZHANG Xinwei, YIN Qiuxiang, LIU Zengkun, GONG Junbo. Autocatalytic kinetics of cefodizime sodium solvate in crystallization[J]. CIESC Journal, 2013, 64(2): 555-560.

张信伟, 尹秋响, 刘增坤, 龚俊波. 头孢地嗪钠溶剂化物结晶过程自催化动力学[J]. 化工学报, 2013, 64(2): 555-560.

References 18

[1]	Kelkheim W M.Process for the preparation of cefodizime sodium:US, 5126445.1992
[2]	Li Aijun(李爱军), Zhou Xueqin(周雪琴), Li Wei(李巍), Liu Dongzhi(刘东志).Synthesis of cefodizime disodium[J].Chinese Journal of Antibiotics (中国抗生素杂志), 2005, 30(6):332-335
[3]	Kelkheim O J, Glashutten H W, Wiesbaden M W.Process for the preparation of cefodizime:US, 4868295.1989
[4]	Frankfurt am Main K H S, Holzappel B M, Frankfurt am Main J B.Crystalline disodium salts of cefodizime :US, 4590267.1986
[5]	Zhang X W, Yin Q X, Cui P L, et al.Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents [J].Ind.Eng.Chem.Res., 2012, 51(19):6933-6938
[6]	Cui P L, Zhang X W, Yin Q X, et al.Evidence of hydrogen-bond formation during crystallization of cefodizime sodium from induction-time measurements and in situ Raman spectroscopy [J].Ind.Eng.Chem.Res., 2012, 51(42):13663-13669
[7]	Marunaka T, Matsushima E, Minami Y, et al.Acidic degradation of cefodizime (THR-221) and structural elucidation of the products(Ⅰ) [J].Chem.Pharm.Bull., 1989, 37(2):367-372
[8]	Matsushima E, Minami Y, Azuma R, et al.Alkaline and neutral degradation of cefodizime (THR-221) and structural elucidation of the products(Ⅱ)[J].Chem.Pharm.Bull., 1989, 37(2):513-515
[9]	Chen Gantang(陈甘棠).Chemical Reaction Engineering (化学反应工程)[M].Beijing:Chemical Industry Press, 2001:10
[10]	Guo Hanxian(郭汉贤).The Application of Chemical Kinetics (应用化工动力学)[M].Beijing:Chemical Industry Press, 2003:11
[11]	Jin Zongde(金宗德).Will raising temperature be of advantage to an exothermic reaction—on the entropy criterion and the free energy criterion of the direction of reactions[J].Chemistry (China) (化学通报), 1982, 434(7):49-51
[12]	Partington J R.A Short History of Chemistry (化学简史)[M].Hu Zuoxuan(胡作玄), trans.Beijing:China Renmin University Press, 2010
[13]	Prout E G, Tompkins F C.The thermal decomposition of potassium permanganate[J].Transactions of the Faraday Society, 1944, 40:488-498
[14]	Brown M E, Glass B D.Pharmaceutical applications of the Prout-Tompkins rate equation[J].International Journal of Pharmaceutics, 1999, 190(2):129-137
[15]	Levenspiel O.The Chemical Reactor(化学反应器)[M].Zheng Yuanyang(郑远扬), Zhao Yongnian(赵永年), trans.Beijing:Science Press, 1985:309
[16]	Sohn H Y, Wadsworth M E.Rate Process of Extractive Metallurgy (提取冶金速率过程)[M].Zheng Diji(郑蒂基), trans.Beijing:Metallurgical Industry Press, 1988
[17]	Moore J W, Pearson R G.Kinetics and Mechanism:A Study of Homogeneous Chemical Reaction (化学动力学和历程:均相化学反应的研究)[M].Sun Cheng'e(孙承谔), Wang Zhipu(王之朴), trans.Beijing:Science Press, 1987:36
[18]	Zhu Bingchen(朱炳辰).Chemical Reaction Engineering (化学反应工程)[M].Beijing:Chemical Industry Press, 1993:11

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Autocatalytic kinetics of cefodizime sodium solvate in crystallization

头孢地嗪钠溶剂化物结晶过程自催化动力学

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