Abstract:

A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole), which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor, and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves, the reactant concentrations at different times were calculated, and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.

Key words:

可视化, 合成硫醚, 浓度-灰度标准曲线, 反应动力学, 液液相界面

摘要： 采用光电显微技术和数字图像跟踪处理技术，实现了液-液界面亚微观环境的可视化。在微型反应器中研究了兰索拉唑中间体硫醚（2-[3-甲基-4-(2，2，2-三氟乙氧基)-2-吡啶基]-硫醚-1H-苯并咪唑）的界面合成反应。用数字图像灰度方法建立了浓度-灰度标准曲线，得到了硫醚界面合成反应动力学曲线和反应速率方程，计算出了咪唑钠和溴代吡啶由主体相到达界面相的总平均传质阻力。

关键词:

可视化, 合成硫醚, 浓度-灰度标准曲线, 反应动力学, 液液相界面