Abstract: A coupling modeling method for integrated control was proposed for determining the optimal coupling point of chemical reaction and separation. Based on the principles of electrochemical reduction reaction and continuous chromatographic separation，the mass transfer equations of reaction and separation were simultaneously solved by using the concentration of electrochemical reaction as the initial boundary conditions for the inputs of the mass transfer equations of continuous chromatographic separation. The influence among the conversion rate of products，the separating efficiency and the electrochemical reaction time were disclosed. The demonstration for the potential of this modeling method was given by its application for the preparation of mannitol. The results showed satisfactory agreement with the experimental data. The method can be effectively used to predict the optimal coupling point of reaction and separation for mannitol preparation，and has the certain promotion application value.

Key words: reaction-separation coupling, mass transfer equation, optimal coupling point, mannitol

摘要： 针对集成反应分离耦合控制中存在最佳耦合点难以确定的技术难点，自主提出了一种能将反应分离进行耦合控制的建模方法。其基于电化学还原反应与连续色谱分离原理，通过将电化学反应方程的浓度值输出作为连续色谱分离传质方程的初始边界条件，耦合两者的传质方程进行联立求解，能够揭示电化学反应时间控制与产物转化率以及分离效果等之间的作用关系。将该方法应用于甘露醇的制备过程，其实验与模拟结果对比表明，两者吻合较好。该建模方法具有较强的预测能力，不仅获得了集成反应分离制备甘露醇的最佳耦合控制点，而且方法具有一定的推广应用价值。

关键词: 反应分离耦合, 传质方程, 最佳耦合点, 甘露醇